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Research Article | Open Access

Computational characterization of hemorheology in the lenticulostriate arteries predicts the location of vessel rupture during hypertensive intracerebral hemorrhage

Zongkun Houa,1, XiaoFei Lia,1, Peng Renb, Yuhua Gonga, TingWang Guoc( ), Paul R. Krafftd, Shilei Haoa( ), Bochu Wanga( )
Key Laboratory of Biorheological Science and Technology, Department of Education, College of Bioengineering, Chongqing University, Chongqing, China
School of Life Sciences and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan, China
College of Environment and Resources, Chongqing Technology and Business University, Chongqing, China
Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA

1 These authors contributed equally to this work.

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Abstract

Hypertensive intracerebral hemorrhage (ICH) is commonly provoked by rupture of basal ganglia and thalamus supplying lenticulostriate arteries (LSAs). The purpose of this study was to identify regions within the LSAs that are prone to rupture. A two-dimensional mathematical model of the LSAs was created in order to identify the location of vascular rupture and a parallel-plate flow chamber was used to evaluate the role of shear stresses on endothelial cell damage. Areas within the LSAs that were prone to rupture were distal parts of the vessels supplying the basal ganglia and thalamus, those located in close proximity to the trunk of the middle cerebral artery (MCA), as well as the vessel wall at the bifurcation point of the LSAs. Furthermore, more severe endothelial cell damage was observed at the origin of the LSAs. This study identified susceptible sites of blood vessel rupture within the LSAs, which, in the future, could be used to anticipate and potentially prevent the occurrence of clinical hypertensive ICH.

Keywords

HypertensionComputational fluid dynamicsEndothelial cellIntracerebral hemorrhageLenticulostriate arteries

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Brain Hemorrhages
Volume 3 Issue 1,
March 2022
Pages 5-13
DOI: 10.1016/j.hest.2021.06.004
Cite this article:
Hou Z, Li X, Ren P, et al. Computational characterization of hemorheology in the lenticulostriate arteries predicts the location of vessel rupture during hypertensive intracerebral hemorrhage. Brain Hemorrhages, 2022, 3(1): 5-13. https://doi.org/10.1016/j.hest.2021.06.004

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Received: 01 May 2021
Revised: 16 June 2021
Accepted: 19 June 2021
Published: 24 June 2021
© 2021 International Hemorrhagic Stroke Association.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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