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Research Article | Open Access

In vitro models of intracerebral hemorrhage

Bilal Syed, Abhijit Nirwane, Yao Yao,a ( )
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA

a ORCID: 0000-0001-8020-9696.

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Abstract

Intracerebral hemorrhage (ICH) is a severe clinical emergency caused by bleeding into brain parenchyma. Currently, there are no effective treatments to improve ICH outcomes. Developing new therapies for ICH relies on a thorough understanding of ICH pathophysiology and good in vitro models that enable mechanistic research. In this review, we summarize commonly used in vitro ICH models and compare their advantages and disadvantages. Next, key questions that need to be answered in future research are discussed. We aim to provide a quick reference/summary of widely used in vitro ICH models and stimulate the development of new models.

Keywords

Intracerebral hemorrhageOxidative stressHemoglobinGlutamateIn vitro modelHemin

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Brain Hemorrhages
Volume 3 Issue 3,
September 2022
Pages 105-107
DOI: 10.1016/j.hest.2022.06.002
Cite this article:
Syed B, Nirwane A, Yao Y. In vitro models of intracerebral hemorrhage. Brain Hemorrhages, 2022, 3(3): 105-107. https://doi.org/10.1016/j.hest.2022.06.002

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Received: 11 June 2022
Accepted: 12 June 2022
Published: 16 June 2022
© 2022 International Hemorrhagic Stroke Association.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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