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Research Article | Open Access

Mitigating the effects of Endothelin-1 following a minimally invasive surgery reduces the blood-brain barrier permeability in a rabbit model of intracerebral hemorrhage

Chen Lia, Xianlin Menga, Likun Wanga( ), Siying Rena, Natahnael Mateib, Guofeng Wua
Emergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang City, Guizhou, China
Department of Ophthalmology, University of Southern California, Los Angeles, CA, United States
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Abstract

Objective

The aim of the current study is to evaluate if ETB inhibition following ICH can mitigate the deleterious impact of ET-1, e.g., BBB disruption, and improve neurological function.

Methods

A total of 90 male rabbits (2.8–3.4 kg) were randomly assigned to the following groups (n = 10 per group): normal control (NC), pseudo-control (PC), drug control using normal saline (DC), model control (MC + ICH), minimally invasive surgery (MIS + ICH), minimally invasive surgery + ET-1 receptor agonist (MIS + IRL1620 + ICH), IRL1620 + ICH, ET-1 receptor antagonist (BQ788 + ICH), and IS + BQ788 + ICH. ICH was induced in all groups except for NC, DC and PC groups.

Results

The purdy score, ET-1, MDA, MMP-9, BWC, and BBB permeability were decreased in groups treated with BQ788 and increased in groups treated with IRL1620. The combination of MIS + BQ788 markedly decreased these deleterious outcomes (purdy score, ET-1, MDA, MMP-9, BWC, and BBB permeability) compared to the MIS group.

Conclusions

Using a non-selective antagonist of ETB, deleterious outcomes associated with increased levels of ET-1 following ICH were ameliorated.

Keywords

Intracerebral hemorrhageMalondialdehydeEndothelin-1ETB receptorMatrix metalloproteinase-9

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Brain Hemorrhages
Volume 3 Issue 4,
December 2022
Pages 177-183
DOI: 10.1016/j.hest.2022.06.004
Cite this article:
Li C, Meng X, Wang L, et al. Mitigating the effects of Endothelin-1 following a minimally invasive surgery reduces the blood-brain barrier permeability in a rabbit model of intracerebral hemorrhage. Brain Hemorrhages, 2022, 3(4): 177-183. https://doi.org/10.1016/j.hest.2022.06.004

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Received: 05 April 2022
Revised: 16 June 2022
Accepted: 20 June 2022
Published: 25 June 2022
© 2022 International Hemorrhagic Stroke Association.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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