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Research Article | Open Access

The effect of atorvastatin on the blood-brain barrier biomarkers in acute intracerebral hemorrhage, a pilot clinical trial

Leila Simania, Mahtab Ramezania,e( ), Nasrin Ahmadib, Fatima Abazaric, Samira Raminfardd, Maziyar Shojaeib, Anahita Zoghib, Ehsan Karimialavijehf, Seyed Hossein Aghamirig, Hossein Pakdamane
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
School of Medicine, Department of Neurology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Advanced Medical Technologies and Equipment Institute, Tehran University of Medical Sciences, Tehran, Iran
Brain Mapping Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sina Hospital, Tehran University of Medical Sciences, Iran
School of Medicine, Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Show Author Information

Abstract

Objective

Prior studies have shown statins provide neuroprotection by targeting secondary brain injury pathways and regulating cytokine production. We aimed to evaluate the association between statin administration and molecular outcomes in acute Intracranial hemorrhages (ICHs).

Methods

Adult patients with acute spontaneous ICH were recruited and randomly allocated into two groups: group A received atorvastatin (40 mg/day) orally in addition to routine antihypertensive medications, while group B only received routine antihypertensives. Serum levels of matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor (VEGF), as primary outcomes, were measured at baseline, and after 45 days.

Results

Thirty-nine ICH patients (group A: 20; group B: 19) were analyzed. A notable elevation in VEGF and a reduction in MMP-9 levels were detected in group A compared to those in group B (P-value = 0.024 and 0.008, respectively).

Conclusion

Our data suggest that atorvastatin in the acute phase of ICH could improve the serum levels of neuroprotective molecular biomarkers.

Keywords

AngiogenesisBlood-brain barrierIntracerebral hemorrhageStatin

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Brain Hemorrhages
Volume 4 Issue 2,
June 2023
Pages 53-56
DOI: 10.1016/j.hest.2022.07.004
Cite this article:
Simani L, Ramezani M, Ahmadi N, et al. The effect of atorvastatin on the blood-brain barrier biomarkers in acute intracerebral hemorrhage, a pilot clinical trial. Brain Hemorrhages, 2023, 4(2): 53-56. https://doi.org/10.1016/j.hest.2022.07.004

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Received: 10 July 2022
Revised: 18 July 2022
Accepted: 21 July 2022
Published: 30 July 2022
© 2022 International Hemorrhagic Stroke Association.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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