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Case Report | Open Access

Intracranial hemorrhage and Covid-19: A retrospective analysis of 1675 hospitalized Covid-19 Brazilian patients

Artur Eduardo Martio( ), Pedro de Moraes Rêgo Soares, Octávio Ruschel Karam, Wagner Lazaretto Padua, Luciano Bambini Manzato, Paulo Moacir Mesquita Filho
Neurosurgery Department, Hospital de Clínicas de Passo Fundo, Passo Fundo, Brazil
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Abstract

Objective

The present study seeks to overcome the lack of data on Covid-19 associated intracranial hemorrhage (ICH) in Brazil.

Methods

This is a retrospective, single-center case series of consecutive patients. It is a subanalysis of a larger study still in progress, which covers all neurological manifestations that occurred in patients admitted between March 1st, 2020 and June 1st, 2022, with active SARS-CoV-2 infection confirmed by polymerase chain reaction test. All patients with non-traumatic ICH were included.

Results

A total of 1675 patients were evaluated: 917 (54.75 %) had one or more neurological symptoms and 19 had non-traumatic ICH, comprising an incidence of 1.13 %. All patients had one or more risk factors for ICH. The presence of neurological manifestations before the ICH and ICU admission showed a statistically significant relationship with the occurrence of ICH (X2 = 6.734, p = 0.0095; OR = 4.47; CI = 1.3–15.4; and FET = 9.13; p = < 0.001; OR = 9.15; CI = 3.27–25.5 respectively).

Conclusion

Our findings were largely congruent with the world literature. We believe that the assessment of risk factors can accurately predict the subgroup of patients at increased risk of ICH, but further studies are needed to confirm these hypotheses.

Keywords

Covid-19Subarachnoid hemorrhageNeurologic manifestationsIntracranial hemorrhagesCerebral parenchymal hemorrhageCerebral intraventricular hemorrhageSubdural hemorrhage

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Brain Hemorrhages
Volume 4 Issue 2,
June 2023
Pages 57-64
DOI: 10.1016/j.hest.2023.01.002
Cite this article:
Martio AE, Soares PdMR, Karam OR, et al. Intracranial hemorrhage and Covid-19: A retrospective analysis of 1675 hospitalized Covid-19 Brazilian patients. Brain Hemorrhages, 2023, 4(2): 57-64. https://doi.org/10.1016/j.hest.2023.01.002

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Received: 23 December 2022
Revised: 10 January 2023
Accepted: 16 January 2023
Published: 19 January 2023
© 2023 International Hemorrhagic Stroke Association.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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