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The present study seeks to overcome the lack of data on Covid-19 associated intracranial hemorrhage (ICH) in Brazil.
This is a retrospective, single-center case series of consecutive patients. It is a subanalysis of a larger study still in progress, which covers all neurological manifestations that occurred in patients admitted between March 1st, 2020 and June 1st, 2022, with active SARS-CoV-2 infection confirmed by polymerase chain reaction test. All patients with non-traumatic ICH were included.
A total of 1675 patients were evaluated: 917 (54.75 %) had one or more neurological symptoms and 19 had non-traumatic ICH, comprising an incidence of 1.13 %. All patients had one or more risk factors for ICH. The presence of neurological manifestations before the ICH and ICU admission showed a statistically significant relationship with the occurrence of ICH (X2 = 6.734, p = 0.0095; OR = 4.47; CI = 1.3–15.4; and FET = 9.13; p = < 0.001; OR = 9.15; CI = 3.27–25.5 respectively).
Our findings were largely congruent with the world literature. We believe that the assessment of risk factors can accurately predict the subgroup of patients at increased risk of ICH, but further studies are needed to confirm these hypotheses.
Ahmad SJ, Feigen CM, Vazquez JP, Kobets AJ, Altschul DJ. Neurological sequelae of COVID-19. J Integr Neurosci. 2022;21(3):77.
Quintanilla-Sánchez C, Salcido-Montenegro A, González-González JG, Rodríguez-Gutiérrez R. Acute cerebrovascular events in severe and nonsevere COVID-19 patients: a systematic review and meta-analysis. Rev Neurosci. 2022;33(6):631-639.
Daly SR, Nguyen AV, Zhang Y, Feng D, Huang JH. The relationship between COVID-19 infection and intracranial hemorrhage: a systematic review. Brain Hemorrhages. 2021;2(4):141-150.
Sojka M, Drelich-Zbroja A, Kuczyńska M, et al. Ischemic and hemorrhagic cerebrovascular events related to COVID-19 coagulopathy and hypoxemia. Int J Environ Res Public Health. 2022;19(18):11823.
Jamora RDG, Prado MB, Anlacan VMM, Sy MCC, Espiritu AI. Incidence and risk factors for stroke in patients with COVID-19 in the Philippines: an analysis of 10,881 cases. J Stroke Cerebrovasc Dis. 2022;31(11):106776.
Margos NP, Meintanopoulos AS, Filioglou D, Ellul J. Intracerebral hemorrhage in COVID-19: A narrative review. J Clin Neurosci. 2021;89:271-278.
Mishra S, Choueka M, Wang Q, et al. Intracranial hemorrhage in COVID-19 patients. J Stroke Cerebrovasc Dis. 2021;30(4):105603.
Decousus H, Tapson VF, Bergmann JF, et al. Factors at admission associated with bleeding risk in medical patients. Chest. 2011;139(1):69-79.
Lechler E, Schramm W, Flosbach CW. The venous thrombotic risk in non-surgical patients: epidemiological data and efficacy/safety profile of a low-molecular-weight heparin (enoxaparin). Pathophysiol Haemost Thromb. 1996;26(Suppl. 2):49-56.
Kleber FX, Witt C, Vogel G, Koppenhagen K, Schomaker U, Flosbach CW. Randomized comparison of enoxaparin with unfractionated heparin for the prevention of venous thromboembolism in medical patients with heart failure or severe respiratory disease. Am Heart J. 2003;145(4):614-621.
Cohen AT, Davidson BL, Gallus AS, et al. Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial. BMJ. 2006;332(7537):325-329.
De A, Roy P, Garg VK, Pandey NK. Low-molecular-weight heparin and unfractionated heparin in prophylaxis against deep vein thrombosis in critically ill patients undergoing major surgery. Blood Coagul Fibrinol. 2010;21(1):57-61.
Mitra J, Kodavati M, Provasek VE, et al. SARS-CoV-2 and the central nervous system: emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations. Ageing Res Rev. 2022;80:101687.
Shchukin IA, Fidler MS, Koltsov IA, Suvorov AY. COVID-19-associated stroke. Neurosci Behav Physiol. 2022;52(5):649-656.
Deana C, Bagatto D. Severe stroke in patients admitted to intensive care unit after COVID-19 infection: pictorial essay of a case series. Brain Hemorrhages. 2021.
Martínez-Salazar B, Holwerda M, Stüdle C, et al. COVID-19 and the vasculature: current aspects and long-term consequences. Front Cell Dev Biol. 2022;10:824851.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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