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Editorial | Open Access

Clazosentan, first approval in Japan: Has perioperative management of subarachnoid hemorrhage changed?

Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Japan
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References

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Macdonald RL, Higashida RT, Keller E, et al. Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2). Lancet Neurol. 2011;10:618–625.

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Macdonald RL, Higashida RT, Keller E, et al. Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling. Stroke. 2012;43:1463–1469.

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Bruder N, Higashida R, Santin-Janin H, et al. The REACT study: design of a randomized phase 3 trial to assess the efficacy and safety of clazosentan for preventing deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. BMC Neurol. 2022;22:492. https://doi.org/10.1186/s12883-022-03002-8.

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Maeda H, Izumo T, Okamura K, et al. Evolving approaches in the management of patients with subarachnoid hemorrhage from 2002 to 2022: the impact of clazosentan and treatment modalities on outcomes. Brain Hemorrhages. 2024;2:55–61. https://doi.org/10.1016/j.hest.2023.11.006.

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Shikata E,, Yamaguchi I, Korai M. Could clazosentan, first approved in Japan, improve neurological prognosis after subarachnoid hemorrhage in combination with modified water-electrolyte management? Brain Hemorrhages. 2024;2:91–97. https://doi.org/10.1016/j.hest.2023.10.005.

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Nishii R, Ohta T, Fukui N,, et al. A high cardiothoracic ratio increases the risk of severe pulmonary complications after early initiation of clazosentan in patients with aneurysmal subarachnoid hemorrhage. Brain Hemorrhages. 2024;2:85–90. https://doi.org/10.1016/j.hest.2023.11.007.

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Suzuki H, Nakajima H, Ichikawa T, et al. Beneficial effects of clazosentan add-on treatment on delayed cerebral microcirculatory disturbances after aneurysmal subarachnoid hemorrhage. Brain Hemorrhages. 2024;2:62–68. https://doi.org/10.1016/j.hest.2023.10.006.

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Itazu T, Ikedo T, Tsutsui T, et al. Impact of strict fluid management on the treatment outcome of clazosentan for cerebral vasospasm. Brain Hemorrhages. 2024;2:69–73. https://doi.org/10.1016/j.hest.2023.12.001.

Brain Hemorrhages
Pages 53-54
Cite this article:
Suzuki H. Clazosentan, first approval in Japan: Has perioperative management of subarachnoid hemorrhage changed?. Brain Hemorrhages, 2024, 5(2): 53-54. https://doi.org/10.1016/j.hest.2023.12.004

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Published: 16 December 2023
© 2023 International Hemorrhagic Stroke Association.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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