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Perspective | Open Access

Fecal microbiota transplantation: A new strategy to delay aging

Haoteng Yan1,2, Jie Ren3,4,5,6( ), Guang-Hui Liu1,2,4,5,7,8( )
Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China
Aging Translational Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing, China
Key Laboratory of RNA Science and Engineering, CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
University of Chinese Academy of Sciences, Beijing, China
Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China
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Abstract

The gut microbiota, the community of gut microorganisms that inhabit the gastrointestinal tract, plays a crucial role in modulating host immunity, metabolism, and neurological health, thereby influencing the entire organism. Aging is associated with changes in gut microbiota composition and functionality, often resulting in dysbiosis, an imbalance of gut microbiota and an aging hallmark. Recent studies have suggested that fecal microbiota transplantation (FMT), the transfer of fecal material containing beneficial microbes from a healthy donor to a recipient with a disturbed microbiota, may restore the balance of host gut microbiota and ameliorate some aging-associated impairments in diverse organs. In particular, FMT from young donors has shown more beneficial effects than FMT from aged donors. In this paper, we review recent advances in FMT for its effects on aging and discuss the potential mechanisms and challenges of this novel intervention, highlighting its potential to improve health outcomes in the aging population.

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hLife
Volume 1 Issue 1,
November 2023
Pages 8-11
DOI: 10.1016/j.hlife.2023.06.002
Cite this article:
Yan H, Ren J, Liu G-H. Fecal microbiota transplantation: A new strategy to delay aging. hLife, 2023, 1(1): 8-11. https://doi.org/10.1016/j.hlife.2023.06.002

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Received: 24 May 2023
Revised: 29 June 2023
Accepted: 30 June 2023
Published: 05 July 2023
© 2023 The Author(s).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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