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Letter | Open Access

Efficient inhibition of SARS-CoV-2 emerging EG.5, EG.5.1 and BA.2.86 variants by fusion inhibitor HY3000 peptide

Lili Wu1,#Anqi Zheng1,2,#Yangming Tang3Xiaoyun Wang1,2Yue Gao1,4Wenwen Lei5Guizhen Wu5Qihui Wang1,2( )George Fu Gao1,2,6
CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
University of the Chinese Academy of Sciences, Beijing, China
Hybio Pharmaceutical Co., Ltd., Guangdong, China
College of Life Science, Hebei University, Hebei, China
NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Chinese Center for Disease Control and Prevention, Beijing, China

#These authors contributed equally to this work

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References

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WHO. EG.5 initial risk evaluation, 9 August 2023 (2023). https://www.who.int/docs/default-source/coronaviruse/09082023eg.5_ire_final.pdf.
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Callaway E. Why a highly mutated coronavirus variant has scientists on alert. Nature 2023;620:934.

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Sun H, Li Y, Liu P, Qiao C, Wang X, Wu L, et al. Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry. Emerg Microb Infect 2020;9:1238–41.

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Wu L, Zheng A, Tang Y, Chai Y, Chen J, Cheng L, et al. A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery. Sci China Life Sci 2023;66:2201–13.

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Hu Y, Zhu Y, Yu Y, Liu N, Ju X, Ding Q, et al. Design and characterization of novel SARS-CoV-2 fusion inhibitors with N-terminally extended HR2 peptides. Antivir Res 2023;212:105571.

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Yang K, Wang C, Kreutzberger AJB, Ojha R, Kuivanen S, Couoh-Cardel S, et al. Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein. Proc Natl Acad Sci USA 2022;119:e2210990119.

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Gao GF. Peptide inhibitors targeting virus-cell fusion in class Ⅰ enveloped viruses. In: Torrence PF, editor. Combating the threat of pandemic influenza: drug discovery approaches. New York: John Wiley & Sons; 2007;226–46.
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hLife
Pages 43-46
Cite this article:
Wu L, Zheng A, Tang Y, et al. Efficient inhibition of SARS-CoV-2 emerging EG.5, EG.5.1 and BA.2.86 variants by fusion inhibitor HY3000 peptide. hLife, 2024, 2(1): 43-46. https://doi.org/10.1016/j.hlife.2023.10.002

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Received: 15 September 2023
Revised: 06 October 2023
Accepted: 07 October 2023
Published: 12 October 2023
© 2023 The Author(s).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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