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Letter | Open Access

BCMA-CD19 bispecific CAR-T therapy in refractory chronic inflammatory demyelinating polyneuropathy

Wei Zhang1,#Dan Liu2,3,4,#Tao Zhang1Jiang Cao5Gang Wang2,3,4Huizhong Li2,3,4Su Zhou1Ruixue Zhang1Yuqiao Wang1Jinyu Li1Zixuan Zhang1Hao Chen1Yong Zhang1Shenyang Zhang1Jie Zu1Xiaopeng Wang1Chuanying Xu1Manli Zhou1Ming Shi2,3,4( )Guiyun Cui1( )Junnian Zheng4( )
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Jiangsu, China
Cancer Institute, Xuzhou Medical University, Jiangsu, China
Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Jiangsu, China
Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, Jiangsu, China
Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Jiangsu, China

#These authors contributed equally to this work

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References

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Hu J, Zhao C, Lin J. Potential therapeutic strategies in chronic inflammatory demyelinating polyradiculoneuropathy. Autoimmun Rev 2022;21:103032.

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Müller F, Taubmann J, Bucci L, Wilhelm A, Bergmann C, Völkl S, et al. CD19 CAR T-cell therapy in autoimmune disease - a case series with follow-up. N Engl J Med 2024;390:687–700.

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Mackensen A, Müller F, Mougiakakos D, Böltz S, Wilhelm A, Aigner M, et al. Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. Nat Med 2022;28:2124–32.

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Mougiakakos D, Krönke G, Völkl S, Kretschmann S, Aigner M, Kharboutli S, et al. CD19-targeted CAR T cells in refractory systemic lupus erythematosus. N Engl J Med 2021;385:567–9.

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Reincke SM, von Wardenburg N, Homeyer MA, Kornau HC, Spagni G, Li LY, et al. Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells. Cell 2023;186:5084–97.e18.

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Wang Y, Cao J, Gu W, Shi M, Lan J, Yan Z, et al. Long-term follow-up of combination of B-cell maturation antigen and CD19 chimeric antigen receptor T cells in multiple myeloma. J Clin Oncol 2022;40:2246–56.

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Ledford H. ‘It’s all gone’: CAR-T therapy forces autoimmune diseases into remission. Nature 2023;624:483–4.

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hLife
Pages 434-438
Cite this article:
Zhang W, Liu D, Zhang T, et al. BCMA-CD19 bispecific CAR-T therapy in refractory chronic inflammatory demyelinating polyneuropathy. hLife, 2024, 2(8): 434-438. https://doi.org/10.1016/j.hlife.2024.05.005

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Received: 12 March 2024
Revised: 22 May 2024
Accepted: 23 May 2024
Published: 28 May 2024
© 2024 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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