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Original Article | Open Access

More precise measurement of irregular splenic volume in cirrhotic patients with portal hypertension

Xiao Chena,1, Tao Yanga,1, Dong Wanga, Bo Huanga, Yanlong Caoa, Jianguo Lub( ), Lei Caia( ), Jikai Yina( )
Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038, China
Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 404100, China

1 These authors contributed equally to this work.

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Abstract

Background and aims

Splenomegaly often occurs in cirrhotic patients with portal hypertension (PHT), and therefore, the efficacy and accuracy of conventional methods for measuring splenic volume are a matter of question in these patients. Here, we developed a novel approach to assess true splenic volume more precisely.

Methods

High-quality thin-slice computed tomography data of 112 cirrhotic patients with PHT were obtained and reviewed. Both the conventional measurement and a novel formula obtained from 3-dimensional reconstruction software were used to estimate splenic volume, and the accuracy was compared and verified.

Results

In PHT patients, the splenic volume calculated using the conventional method was significantly less than that calculated using the 3-dimensional software. We found that the splenic volume was significantly positively correlated with splenic indices of length (L), thickness (T), and width (W) and also the diameter of the splenic vein. Using these indices, we propose 2 novel formulas using the software to estimate the splenic volume more accurately: SV = 69.686 × L + 53.077 × W + 103.525 × T + 314.510 × diameter of splenic vein −2266.209 (p < 0.01, R2 = 0.805). And a more practical simplified formula: SV' = 0.504 × L × W × Τ + 319.762 × diameter of splenic vein −81.66 (p < 0.01, R2 = 0.784).

Conclusion

Although the conventional formula has been widely used for years, it is not suitable for an enlarged spleen. We developed 2 novel formulas for estimating splenic volume from clinical data that were more appropriate for cirrhotic patients with PHT.

Keywords

Liver cirrhosisPortal hypertensionSplenic volume

Electronic Supplementary Material

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iLIVER
Volume 2 Issue 2,
June 2023
Pages 109-115
DOI: 10.1016/j.iliver.2023.04.002
Cite this article:
Chen X, Yang T, Wang D, et al. More precise measurement of irregular splenic volume in cirrhotic patients with portal hypertension. iLIVER, 2023, 2(2): 109-115. https://doi.org/10.1016/j.iliver.2023.04.002

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Received: 23 February 2023
Revised: 16 April 2023
Accepted: 25 April 2023
Published: 22 May 2023
© 2023 The Authors. Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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