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Original Article | Open Access

Radiomic features on contrast-enhanced images of the remnant liver predict the prognosis of hepatocellular carcinoma after partial hepatectomy

Meilong Wua,b,c, Liping Liua,b,c, Xiaojuan Wangd,e,f,g, Ying Xiaof,h, Shizhong Yangd,e,f,g( ), Jiahong Dongd,e,f,g( )
Division of Hepatobiliary and Pancreas Surgery, Department of General Surgery, Shenzhen People’s Hospital, Shenzhen 518020, China
The Second Clinical Medical College, Jinan University, Shenzhen 518020, China
The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China
Hepato-pancreato-biliary Center, Beijing Tsinghua Changgung Hospital, Beijing 102218, China
Key Laboratory of Digital Intelligence Hepatology, Chinese Ministry of Education , Beijing 102218, China
School of Clinical Medicine, Tsinghua University, Beijing 100084, China
Research Unit of Precision Hepatobiliary Surgery Paradigm, Chinese Academy of Medical Sciences, Beijing 102218, China
Department of Pathology, Beijing Tsinghua Changgung Hospital, Beijing 102218, China
Show Author Information

Abstract

Background and aims

Radiomic features extracted from preoperative contrast-enhanced computed tomography (CT) images have been shown to predict the prognosis of hepatocellular carcinoma (HCC). However, the prognostic role of radiomic features obtained from postoperative contrast-enhanced CT images of the remnant liver remains unclear. This study explored the prognostic value of radiomic features extracted from postoperative contrast-enhanced CT images in patients with HCC.

Methods

Robust radiomic features were obtained from postoperative contrast-enhanced CT images for 78 patients with primary HCC and used to construct a radiomics score. A clinical model and a combined model that integrated clinicopathological indicators and the radiomics score were established. The predictive performance of the model was assessed using the concordance index and net reclassification index.

Results

The postoperative radiomics score for the remnant liver was an independent prognostic factor for disease-free survival (DFS) and overall survival (OS). The combined model was not inferior to the clinical model in predicting DFS but was superior in predicting OS. The net reclassification index confirmed that the combined model was more accurate and efficient in predicting OS and DFS. The radiomics score for DFS was significantly associated with tumor thrombus in the portal vein and the postoperative neutrophil-lymphocyte ratio. The radiomics score for OS was associated with multiple tumors, microvascular invasion, and tumor thrombus in the portal vein.

Conclusion

Postoperative contrast-enhanced CT radiomic features of the remnant liver were valuable prognostic indicators that could potentially reflect tumor burden and postoperative inflammatory status and provide more information for clinical decision-making.

Keywords

Hepatocellular carcinomaSurvivalRadiomicsComputed tomographyPostoperativeRemnant

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iLIVER
Volume 3 Issue 1,
March 2024
DOI: 10.1016/j.iliver.2024.100079
Cite this article:
Wu M, Liu L, Wang X, et al. Radiomic features on contrast-enhanced images of the remnant liver predict the prognosis of hepatocellular carcinoma after partial hepatectomy. iLIVER, 2024, 3(1). https://doi.org/10.1016/j.iliver.2024.100079

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Received: 29 October 2023
Revised: 02 December 2023
Accepted: 12 December 2023
Published: 06 February 2024
© 2024 The Author(s). Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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