AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Journal of Traditional Chinese Medical Sciences Article
PDF (397.5 KB)
Cite
EndNote(RIS) BibTeX
Collect
AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Original Article | Open Access

Association between body-constitution type and vascular endothelial dysfunction: A cross-sectional study in an adult obese/overweight population

Ranran Suna, Lingru Lia, Haiqiang Yaob, Yu Chenc, Pin Lia, Jianxiang Suna, Yuehua Qina, Xin Wanga, Qi Wanga( )
Center for Studies in Constitution Research of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA
China-Japan Friendship Hospital, Beijing 100029, China

Peer review under responsibility of Beijing University of Chinese Medicine.

Show Author Information

Abstract

Objective

To measure vascular endothelial function (VED) in obese/overweight people grouped according to the constitutional theory of traditional Chinese medicine (TCM). We wished to predict the risk of VED and cardiovascular diseases in obese/overweight populations.

Methods

This was a cross-sectional study. Eighty-six obese/overweight volunteers from Beijing Chao-Yang Hospital were enrolled and divided into four groups based on body-constitution type: phlegm dampness (PD); phlegm dampness with blood stasis (PDBS); qi-deficiency (QD); balance (BA). Height, weight, waist circumference and hip circumference were measured, and percent body fat and reactive hyperemia index (RHI) calculated. Levels of vascular endothelial growth factor (VEGF), von Willebrand factor (vWF) and plasma endothelial-1 (ET-1) were detected by immunohistochemistry.

Results

The RHI and vWF levels in the PDBS group were significantly lower than those in the BA group and QD group (P < .05), but there was no significant difference compared with the PD group (P > .05). These two indicators displayed no significant differences among BA, QD, and PD groups (P > .05). There was no significant difference among the four groups in level of ET-1 or VEGF (P > .05).

Conclusion

Of the four indicators selected, the RHI and vWF displayed significant differences between the PDBS group and BA group, and between the PDBS group and QD group. Hence, in an obese/overweight population with different constitutional types, compared with BA and QD groups, a relatively higher risk of suffering from VED was detected in the PDBS group. Meanwhile, this study provides the experimental basis for confirming the feasibility of constitutional classification in obese/overweight population.

Keywords

Constitution classificationObese/overweightVascular endothelial dysfunctionReactive hyperemia index

References

1
World Health Organization. Obesity and Overweight Fact Sheet; Reviewed February 2018. WHO Web site. http://www.who.int/mediacentre/factsheets/fs311/en/. Accessed March 1, 2018.
2

Nguyen T, Lau DC. The obesity epidemic and its impact on hypertension. Can J Cardiol. 2012;28(3):326–333.
Crossref Google Scholar
3

Kim NH, Seo JA, Cho H, et al. Risk of the development of diabetes and cardiovascular disease in metabolically healthy obese people: the Korean genome and epidemiology study. Medicine (Baltim). 2016;95(15):e3384.
Crossref Google Scholar
4

Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects), Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm EB, Danaei G, et al. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants. Lancet. 2014;383(9921):970–983.
Crossref Google Scholar
5

Aune D, Sen A, Norat T, et al. Body mass index, abdominal fatness, and heart failure incidence and mortality: a systematic review and dose-response meta-analysis of prospective studies. Circulation. 2016;133(7):639–649.
Crossref Google Scholar
6

Park SY, Wilkens LR, Maskarinec G, Haiman CA, Kolonel LN, Marchand LL. Weight change in older adults and mortality: the multiethnic cohort study. Int J Obes (Lond). 2018;42(2):205–212.
Crossref Google Scholar
7

Sun ZH. Clinical comparison of intravascular ultrasound and coronary angiography in patients with coronary heart disease. China Med Eng. 2014;22(1):154–155 [Chinese].
Google Scholar
8

Gimbrone Jr MA, García-Cardeña G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res. 2016;118(4):620–636.
Crossref Google Scholar
9

Cahill PA, Redmond EM. Vascular endothelium-Gatekeeper of vessel health. Atherosclerosis. 2016;248:97–109.
Crossref Google Scholar
10

Garg PK, McClelland RL, Jenny NS, et al. Association of lipoprotein-associated phospholipase A(2) and endothelial function in the Multi-Ethnic Study of Atherosclerosis (MESA). Vasc Med. 2011;16(4):247–252.
Crossref Google Scholar
11

Goettsch C, Rauner M, Sinningen K, et al. The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells. Endocrinology. 2011;152(12):4915–4926.
Crossref Google Scholar
12

Gupta AK, Ravussin E, Johannsen DL, Stull AJ, Cefalu WT, Johnson WD. Endothelial dysfunction: an early cardiovascular risk marker in asymptomatic obese individuals with prediabetes. Br J Med Med Res. 2012;2(3):413–423.
Crossref Google Scholar
13

Hashimoto M, Akishita M, Eto M, et al. The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation. Int J Obes Relat Metab Disord. 1998;22(5):477–484.
Crossref Google Scholar
14

Nakamura K, Fuster JJ, Walsh K. Adipokines: a link between obesity and cardiovascular disease. J Cardiol. 2014;63(4):250–259.
Crossref Google Scholar
15

Ruderman NB, Schneider SH, Berchtold P. The “metabolically-obese,” normal-weight individual. Am J Clin Nutr. 1981;34(8):1617–1621.
Crossref Google Scholar
16

Ruderman N, Chisholm D, Pi-Sunyer X, Schneider S. The metabolically obese, normal-weight individual revisited. Diabetes. 1998;47(5):699–713.
Crossref Google Scholar
17

Zhu YB, Wang Q, Wu CY, et al. Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. J Integr Med. 2010;8(11):1023–1026 [Chinese].
Crossref Google Scholar
18
Jing HR. Exploration of Constitution in Chinese Medicine Questionnaire in English Version and its Epidemiological Survey in American and Canadian Caucasians [dissertation]. Beijing: Beijing University of Chinese Medicine; 2012 [Chinese].
19

Schoenenberger AW, Urbanek N, Bergner M, Toggweiler S, Resink TJ, Erne P. Associations of reactive hyperemia index and intravascular ultrasound-assessed coronary plaque morphology in patients with coronary artery disease. Am J Cardiol. 2012;109(12):1711–1716.
Crossref Google Scholar
20
Wang Q. Traditional Chinese Medicine Constitutionology in 2008. Beijing: People’s Medical Publishing House; 2009 [Chinese].
21

Wang Q. Chinese precision medicine: nine constitution medical health program. Chin J Tradit Chin Med Pharm. 2015;10(30):3407–3411 [Chinese].
Google Scholar
22

Rubinshtein R, Kuvin JT, Soffler M, et al. Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events. Eur Heart J. 2010;31(9):1142–1148.
Crossref Google Scholar
23

Corey KE, Kartoun U, Zheng H, Chung RT, Shaw SY. Using an electronic medical records database to identify non-traditional cardiovascular risk factors in nonalcoholic fatty liver disease. Am J Gastroenterol. 2016;111(5):671–676.
Crossref Google Scholar
24

Bugnicourt JM, Roussel B, Tramier B, Lamy C, Godefroy O. Cerebral venous thrombosis and plasma concentrations of factor VIII and von Willebrand factor: a case control study. J Neurol Neurosurg Psychiatry. 2007;78(7):699–701.
Crossref Google Scholar
25

Lip GY, Blann AD. von-Willebrand factor and its relevance to cardiovascular disorders. Br Heart J. 1995;74(6):580–583.
Crossref Google Scholar
26

Dong WS, Li XX, Yang J. The role of endothelin-1 in the cardiovascular system. Int J Cardiovasc Dis. 2012;39(3):153–156 [Chinese].
Crossref Google Scholar
27

Valero-Munoz M, Li S, Wilson RM, Boldbaatar B, Iglarz M, Sam F. Dual endothelin-A/endothelin-B receptor blockade and cardiac remodeling in heart failure with preserved ejection fraction. Circ Heart Fail. 2016. https://doi.org/10.1161/CIRCHEARTFAILURE.116.003381.
Crossref Google Scholar
28

Ohkita M, Tawa M, Kitada K, Matsumura Y. Pathophysiological roles of endothelin receptors in cardiovascular diseases. J Pharmacol Sci. 2012;119(4):302–313.
Crossref Google Scholar
29

Bonadei I, Vizzardi E, D'Aloia A, Sciatti E, Raddino R, Metra M. Role of aliskiren on arterial stiffness and endothelial function in patients with primary hypertension. J Clin Hypertens (Greenwich). 2014;16(3):202–206.
Crossref Google Scholar
30

Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288(5789):373–376.
Crossref Google Scholar
31

Li ZG, Liu XR. Yellow Emperor's cancon of Medicine·Plain conversation. Xian China Xian World Publ Corp. 2005:512–521 [Chinese].
Google Scholar
Journal of Traditional Chinese Medical Sciences
Volume 5 Issue 2,
April 2018
Pages 94-99
DOI: 10.1016/j.jtcms.2018.05.003
Cite this article:
Sun R, Li L, Yao H, et al. Association between body-constitution type and vascular endothelial dysfunction: A cross-sectional study in an adult obese/overweight population. Journal of Traditional Chinese Medical Sciences, 2018, 5(2): 94-99. https://doi.org/10.1016/j.jtcms.2018.05.003

276

Views

5

Downloads

1

Crossref

0

Scopus

Altmetrics
Received: 07 December 2017
Revised: 04 May 2018
Accepted: 16 May 2018
Published: 25 May 2018
© 2018 Beijing University of Chinese Medicine.

This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Return