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Original Article | Open Access

Does the traditional Chinese medicine theory of five circuits and six qi improve treatment effectiveness? A systematic review of randomized controlled trials

Qiaoling Tang, Yu Hao, Jia Song, Lingzhi Sun, Juan He( )
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

Peer review under responsibility of Beijing University of Chinese Medicine.

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Abstract

Objective

To evaluate whether the traditional Chinese medicine (TCM) theory of five circuits and six qi (FCSQ) is beneficial in terms of improving clinical effectiveness.

Methods

Randomized controlled trials (RCTs) evaluating the clinical value of FCSQ theory were reviewed. Multiple databases (China Network Knowledge Infrastructure, Chinese Scientific Journals Database, Wanfang Data, SinoMed, Cochrane Library, PubMed, and Embase) were systematically searched from inception to June 12, 2018. Two authors independently extracted the data and performed a methodological quality assessment of the RCTs. RevMan 5.3 software was used for the data analysis. The effect sizes for the primary outcome measures were expressed as relative risks or mean differences with 95% confidence intervals.

Results

A total of 13 RCTs were selected, involving 12 types of diseases and 4695 patients. The methodological quality of the RCTs was generally low. Five studies compared the effectiveness of TCM treatments guided by FCSQ theory with conventional TCM therapies, and the remaining eight studies compared the effectiveness of TCM treatments guided by FCSQ theory with biomedical treatments. All of the RCTs reported that the effectiveness of the treatment intervention was better than that of the intervention in the control group.

Conclusion

Because of many methodological problems in existing clinical studies, it remains impossible to definitively conclude that FCSQ theory can improve clinical effectiveness. It is difficult to unify the clinical application of FCSQ theory. The feasibility and repeatability of FCSQ as an intervention should be given more attention in future clinical research. Future work should also follow international norms for clinical research implementation and reporting to provide high-quality evidence for evaluating the clinical value of FCSQ theory.

Keywords

EvaluationEffectivenessRandomized controlled trialFive circuits and six qi

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Journal of Traditional Chinese Medical Sciences
Volume 5 Issue 4,
October 2018
Pages 350-360
DOI: 10.1016/j.jtcms.2018.12.004
Cite this article:
Tang Q, Hao Y, Song J, et al. Does the traditional Chinese medicine theory of five circuits and six qi improve treatment effectiveness? A systematic review of randomized controlled trials. Journal of Traditional Chinese Medical Sciences, 2018, 5(4): 350-360. https://doi.org/10.1016/j.jtcms.2018.12.004

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Received: 17 September 2018
Revised: 11 November 2018
Accepted: 12 December 2018
Published: 17 December 2018
© 2019 Beijing University of Chinese Medicine. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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