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Original Article | Open Access

Characteristics of 240 randomized controlled trials for adjusting constitution in preventive treatment of disease: A bibliometric analysis

Wenjun Yua,1, Shenglou Nib,1, Qianru Lia, Mingyue Maa, Ya'nan Pengc, Weidong Yud, Hua Jine, Pengting Zhanga, Qi Wanga( )
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Periodicals Publishing Center, Beijing University of Chinese Medicine, Beijing 100029, China
Wang Jing Hospital of CACMS, Beijing 100102, China
Wellspring TCM Technology Institute, Vancouver V5Z2E2, Canada
Technology and Development Center for TCM of China, Beijing 100027, China

Peer review under responsibility of Beijing University of Chinese Medicine.

1 These two authors contributed equally in this article.

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Abstract

Background

A growing number of randomized controlled trials (RCTs) have explored the significance of adjusting constitution for preventive treatment of disease in traditional Chinese medicine (TCM). In this study, we sought to comprehensively analyze the characteristics of these RCTs.

Methods

All RCTs related to constitutional adjustment and preventive treatment of disease were included in the study. Literature was screened searching seven databases, including Pubmed, Web of Science, Embase, SinoMed, CNKI, Chongqing VIP, and Wangfang Database, from inception to December 2018. Data pertaining to bibliometrics, participants, and interventions were extracted and analyzed.

Results

Two hundred and forty papers were published between 2007 and 2018, involving 240 RCTs with 55977 total participants. Sample size in these RCTs ranged from 30 to 7800. Among them, 59 RCTs addressed disease prevention prior to onset involving 11 healthy states of participants, mainly for general health or sub-health population (40.68%) using health care and non-drug therapy. In control the development of existing disease (n = 174), 59 diseases were involved. Based on the number of RCTs and sample sizes, diseases including type 2 diabetes mellitus, primary hypertension, nonalcoholic fatty liver disease, and hyperlipoproteinemia accounted for 51.15% of the total patients studied. Drug therapy as an intervention was frequently used. In preventing recurrence after recovery (n = 7), over 4 kinds of health status in participants were involved. Drug therapy combined with health care was mostly used. Most RCTs reported positive outcomes, with only one reporting negative findings (1/240).

Conclusion

The number of RCTs of constitutional adjustment on preventive treatment of disease has gradually increased since 2012. Participants and intervention measures from the above-mentioned types of RCTs exhibit their own characteristics. Future systematic reviews or meta-analyses on constitutional adjustment for preventive treatment of disease are warranted.

Keywords

BibliometricsRandomized controlled trialsTraditional Chinese medicine constitutionConstitutional adjustmentPreventive treatment of disease

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Journal of Traditional Chinese Medical Sciences
Volume 6 Issue 3,
July 2019
Pages 226-233
DOI: 10.1016/j.jtcms.2019.08.003
Cite this article:
Yu W, Ni S, Li Q, et al. Characteristics of 240 randomized controlled trials for adjusting constitution in preventive treatment of disease: A bibliometric analysis. Journal of Traditional Chinese Medical Sciences, 2019, 6(3): 226-233. https://doi.org/10.1016/j.jtcms.2019.08.003

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Received: 02 July 2019
Revised: 10 August 2019
Accepted: 11 August 2019
Published: 16 August 2019
© 2019 Beijing University of Chinese Medicine.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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