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Original Article | Open Access

Preparation of Dashanzha Wan by three-dimensional printing

Fengyuan Qin, Zifan Ding, Cong Yan( )
School of Life Science, Beijing University of Chinese Medicine, Beijing 102488, China

Peer review under responsibility of Beijing University of Chinese Medicine.

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Abstract

Objective

To use three-dimensional (3D) printing technology to prepare Dashanzha Wan.

Methods

The standard formula proportion of Dashanzha Wan was used to prepare printable materials (normally called the ink) for 3D printing, and different doses and shapes of Dashanzha Wan were prepared. Then, the rheological properties, texture characteristics, scanning electron microscopy, and content of ursolic acid were evaluated.

Results

Dashanzha Wan ink showed good shear thinning properties, which is very suitable for 3D printing. The printed sample had a beautiful and regular shape with high resolution. Meanwhile, ursolic acid content in 3D-printed Dashanzha Wan aligned with the ursolic acid content shown in the Pharmacopoeia of the People's Republic of China 2020.

Conclusion

The 3D-printed Dashanzha Wan has a better texture, and can be shaped into various shapes according to individual needs, which would increase patients’ interest when taking medicine. Moreover, 3D printing of Dashanzha Wan could be easily integrated into the digital life system, enabling online customization or use at home. This study reveals that 3D printing technology is a promising method for the production of traditional Chinese medicine with personalized appearance, dosage, and texture, which is suitable for a broader population.

Keywords

Three-dimensional printingDashanzha WanCustomized appearanceRheological propertiesTextural analysisMicrostructure observationUrsolic acidPreparation process

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Journal of Traditional Chinese Medical Sciences
Volume 10 Issue 1,
January 2023
Pages 52-57
DOI: 10.1016/j.jtcms.2022.11.004
Cite this article:
Qin F, Ding Z, Yan C. Preparation of Dashanzha Wan by three-dimensional printing. Journal of Traditional Chinese Medical Sciences, 2023, 10(1): 52-57. https://doi.org/10.1016/j.jtcms.2022.11.004

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Received: 17 June 2022
Revised: 25 November 2022
Accepted: 26 November 2022
Published: 02 December 2022
© 2023 Beijing University of Chinese Medicine.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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