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Review Article | Open Access

Scientific connotation of “treating different diseases with the same method” from the perspective of metabolic–immune dysregulation in inflammation-mediated carcinogenesis of digestive organs

Xia Dinga,b,c,1, Yunze Liua,1, Ruilin Wangd, Hong Shene, Qi Wangf( )
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China
Centre of Research for Traditional Chinese Medicine Digestive, Beijing University of Chinese Medicine, Beijing 100029, China
Department of Hepatology of Traditional Chinese Medicine, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China
Digestive Department, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China
National Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

Peer review under responsibility of Beijing University of Chinese Medicine.

1 These authors have contributed equally to this work.

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Abstract

Inflammation-mediated carcinogenesis develops in the context of chronic inflammation and is a significant cause of cancer within the digestive system. In the chronic inflammation microenvironment, the metabolic activity of tissue cells undergoes extensive changes, which interfere with the normal function of immune cells. Dysregulation of cell metabolism and immune function has been identified as a key factor contributing to inflammation-mediated carcinogenesis within the major digestive organs, such as the stomach, liver, and colorectum. This metabolic–immune imbalance also corresponds to traditional Chinese medicine (TCM) theories of “yin-yang disharmony” and “disharmony between Ying-nutrients and Wei-defense.” The metabolic–immune imbalance has also been regarded as the key factor supporting “treatment of different diseases with the same method,” in which the same approach is adopted in the treatment of different conditions. In the TCM treatment process, it is necessary to first identify TCM patterns and then apply the corresponding TCM to correct the dysregulated metabolic and immune function, thereby blocking the progression from inflammation to malignancy. Our study findings deepen the TCM understanding of metabolic–immune dysregulation and the relationship between metabolic–immune dysregulation, pattern identification, and treatment method. They also provide new insights for the treatment of inflammation-mediated carcinogenesis in major digestive organs and help us further explore the scientific connotation of the TCM strategy of “treating different diseases with the same method.

Keywords

MetabolismImmunityInflammation-mediated carcinogenesisTreating different diseases with the same methodMetabolic–immune regulationDigestive system

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Journal of Traditional Chinese Medical Sciences
Volume 10 Issue 1,
January 2023
Pages 3-9
DOI: 10.1016/j.jtcms.2022.12.001
Cite this article:
Ding X, Liu Y, Wang R, et al. Scientific connotation of “treating different diseases with the same method” from the perspective of metabolic–immune dysregulation in inflammation-mediated carcinogenesis of digestive organs. Journal of Traditional Chinese Medical Sciences, 2023, 10(1): 3-9. https://doi.org/10.1016/j.jtcms.2022.12.001

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Received: 09 November 2022
Revised: 03 December 2022
Accepted: 04 December 2022
Published: 07 December 2022
© 2022 Beijing University of Chinese Medicine.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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