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Original Article | Open Access

Characteristics of Xiao Chai Hu decoction based on randomized controlled trials: A bibliometric analysis

Zhongyi Pana,1, Mei Hanb,1, Yifei Zhanga, Tianzhe Liuc, Lijun Zhouc, Daiying Tanc, Qi Wangc, Zhe Liuc, Yanling Fua( )
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China
Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 102488, China

Peer review under responsibility of Beijing University of Chinese Medicine.

1 These authors have contributed equally to this work.

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Abstract

Objective

To explore the characteristics of Xiao Chai Hu (XCH) decoction in randomized controlled trials (RCTs) using a bibliometric method.

Methods

Seven databases including PubMed, Web of Science, Embase, Cochrane library, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP) and Wanfang database were retrieved from inception to May 27, 2022. In the study, XCH decoction (or modified) used alone or combined with conventional Western medicine as an intervention measure was included. The basic characteristics, funding support, relevant diseases, intervention methods, and adverse events (AEs) were analyzed. Data analysis was performed using SPSS 26.0 software.

Results

A total of 813 RCTs were included, published from 1989 to 2022. There was only one English-language literature with the recent impact factor of 5.374. There were 147 studies were from Chinese-language core journals, with the highest impact factor of 2.414. Only 6.15% of the literatures mentioned funding support. 96.31% of the included literature reported the statistical significance of using XCH decoction. The diseases treated mainly included chronic hepatitis B (9.35%), cough variant asthma (5.66%), dizziness (5.54%), bile reflux gastritis (4.43%), and fever (4.18%). However, the overall research design of the included literature was poor, and large sample size, multicenter RCTs are needed. The incidence of AEs of XCH decoction alone was 8.86%, which was significantly lower than that of conventional Western medicine treatment. The combination of XCH decoction and conventional Western medicine treatment could reduce the incidence of AEs, and no serious adverse event was reported.

Conclusion

Although the included studies show that XCH decoction is widely used, and has good efficacy and few AEs. Due to the low quality of the included RCTs, there may be some bias, and its rational use based on the specific conditions is recommended in clinical practice.

Keywords

Randomized controlled trialBibliometricXiao Chai Hu decoctionSho-Saiko-toAdverse events

References

1

Li X, Li X, Gong M, et al. Modified Xiaochaihu decoction combined with mirtazapine in the treatment of persistent depression: a pilot randomized controlled trial. Contrast Media Mol Imaging. 2022;2022:8682612.
Crossref Google Scholar
2

Xu LY, Yu BY, Cen LS. New treatment for gastroesophageal reflux disease: traditional Chinese medicine Xiaochaihu decoction. World J Gastroenterol. 2022;28(11):1184-1186.
Crossref Google Scholar
3

Li M, Dan W, Zhang H, Yun Y, He Q. Xiao Chai Hu Tang for peptic ulcers: a systematic review and meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med. 2021;2021:6693677.
Crossref Google Scholar
4

Zhu W, Luo H, Xiong M, Shen T. Xiaochaihu decoction for nonalcoholic fatty liver disease: a protocol for a systematic review and meta-analysis. Medicine. 2021;100(12):e25267.
Crossref Google Scholar
5

Kong Z, Liang N, Yang GL, et al. Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B. Cochrane Database Syst Rev. 2019;2019(11):CD013090.
Crossref Google Scholar
6

Zheng XY, Liang R. Investigation of applying Xiaochaihu decoction in Japanese Kampo medicine. Acta Chin Med Pharmacol. 2008;36(2):23-26 [Chinese].
Google Scholar
7

Tsukiyama K, Tasaka Y, Nakajima M, et al. A case of pneumonitis due to sho-saiko-to. Nihon Kyobu Shikkan Gakkai Zasshi. 1989;27(12):1556-1561 [Japanese].
Google Scholar
8

Daibo A, Yoshida Y, Kitazawa S, Kosaka Y, Bando T, Sudo M. A case of pneumonitis and hepatic injury caused by a herbal drug (sho-saiko-to). Nihon Kyobu Shikkan Gakkai Zasshi. 1992;30:1583-1588.
Google Scholar
9

Takada N, Arai S, Kusuhara N, et al. A case of sho-saiko-to-induced pneumonitis, diagnosed by lymphocyte stimulation test using bronchoalveolar lavage fluid. Nihon Kyobu Shikkan Gakkai Zasshi. 1993;31(9):1163-1169 [Japanese].
Google Scholar
10

Nakagawa A, Yamaguchi T, Takao T, Amano H. Five cases of drug-induced pneumonitis due to Sho-saiko-to or interferonalpha or both. Nihon Kyobu Shikkan Gakkai Zasshi. 1995;33:1361-1366 [Japanese].
Google Scholar
11
Serious adverse effect "interstitial pneumonia" caused by administration of shosaikoto: from Pharmaceuticals Safety Information No. 137 (May 1996). Nihon Toyo Igaku Zasshi. 1996;47:81-83 [Japanese].
12

Hsu LM, Huang YS, Tsay SH, Chang FY, Lee SD. Acute hepatitis induced by Chinese hepatoprotective herb, xiao-chai-hu-tang. J Chin Med Assoc. 2006;69(2):86-88.
Crossref Google Scholar
13

Lee JK, Kim JH, Shin HK. Therapeutic effects of the oriental herbal medicine Sho-saiko-to on liver cirrhosis and carcinoma. Hepatol Res. 2011;41(9):825-837.
Crossref Google Scholar
14

Liu JP. The composition of evidence body of traditional medicine and recommendations for its evidence grading. Chin J Integr Tradit West Med. 2007;27(12):1061-1065 [Chinese].
Google Scholar
15

Gao JK. Application of bibliometrics methods in scientific evaluation. Doc Inf Knowl. 2005(2):14-17 [Chinese].
Google Scholar
16

An Y, Zhang L. Applied research summary on bibliometrics in library and information field. Library. 2014(5):63-68. [Chinese].
Google Scholar
17

Dayuan Z, Lan L, Luhua X, et al. A bibliometric analysis of research related Chinese Medicine in the prevention and treatment of corona virus disease 2019. Heliyon. 2022;8(11):e11120.
Crossref Google Scholar
18

Nie CC, Su KQ, Gao J, et al. Bibliometric analysis: research trends of acupuncture treatment to cognitive impairment in recent 15 years. Front Psychol. 2022;13:935053.
Crossref Google Scholar
19
Institute of Scientific and Technical Information of China. Chinese S&T Journal Citation Reports (Natural Science). Beijing, China: Scientific and Technical Documentation Press; 2021 [Chinese].
20
World Health Organization. https://icd.who.int/browse11/l-m/en, accessed November 11, 2022.
21

Lin Y. Common problems and countermeasures in rational use of Xiaochaihu decoction. Strait Pharm J. 2018;30(4):220-221 [Chinese].
Google Scholar
22

Li Z, Tao L, Zhang SS, Sun XH, Chen SN, Wu J. Modified Xiaochaihu decoction for gastroesophageal reflux disease: a randomized double-simulation controlled trial. World J Gastroenterol. 2021;27(28):4710-4721.
Crossref Google Scholar
23

Guan DL, Hu YM, Qiu XY, Wu SG. Visual analysis of related research of Xiaochaihu decoction based on Citespace. Guid J Tradit Chin Med Pharm. 2022;28(5):147-151 [Chinese].
Google Scholar
24

Wang HJ, Ma GQ. Introduction to Professor Ma Guiqin's experience in treatment of occupational pneumoconiosis. China J Chin Mater Med. 2019;44(13):2871-2874 [Chinese].
Google Scholar
25

Dou Z, Xia Y, Zhang J, et al. Syndrome differentiation and treatment regularity in traditional Chinese medicine for type 2 diabetes: a text mining analysis. Front Endocrinol. 2021;12:728032.
Crossref Google Scholar
26

Doctor Society of integrative Medicine, Chinese Medical Doctor Association, Evidence-based Medical Specialty Board, Chinese Association of Integrative Medicine. Guidelines on clinical research methods of traditional Chinese medicine and integrated traditional Chinese and Western medicine. Chin J Integr Tradit West Med. 2015;35(8):901-932 [Chinese].
Google Scholar
27

Schulz KF, Altman DG, Moher D, CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. BMJ. 2010;340:c332.
Crossref Google Scholar
28

Gagnier JJ, Boon H, Rochon P, Moher D, Barnes J, Bombardier C; CONSORT Group. Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement. Ann Intern Med. 2006;144(5):364-367.
Crossref Google Scholar
29

Li XX, Han M, Wang YY, Liu JP. International registration of clinical trials and significance and methods of registration in ClinicalTrials.gov. J Tradit Chin Med. 2013;54(19):1640-1643 [Chinese].
Google Scholar
Journal of Traditional Chinese Medical Sciences
Volume 10 Issue 1,
January 2023
Pages 100-105
DOI: 10.1016/j.jtcms.2022.12.003
Cite this article:
Pan Z, Han M, Zhang Y, et al. Characteristics of Xiao Chai Hu decoction based on randomized controlled trials: A bibliometric analysis. Journal of Traditional Chinese Medical Sciences, 2023, 10(1): 100-105. https://doi.org/10.1016/j.jtcms.2022.12.003

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Received: 16 November 2022
Revised: 05 December 2022
Accepted: 06 December 2022
Published: 09 December 2022
© 2023 Beijing University of Chinese Medicine.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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