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Review Article | Open Access

Nanomaterial-assisted wearable glucose biosensors for noninvasive real-time monitoring: Pioneering point-of-care and beyond

Moein Safarkhania,1Abdullah Aldhaherb,1Golnaz HeidaricEhsan Nazarzadeh ZaredMajid Ebrahimi Warkianie( )Omid AkhavanfYunSuk Huha( )Navid Rabieef,g,h ( )
NanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon, 22212, Republic of Korea
Department of Chemistry, Sharif University of Technology, Tehran, Iran
School of Natural Sciences, Massey University, Private Bag 11 222, Palmerston North, 4410, New Zealand
School of Chemistry, Damghan University, Damghan, 36716-45667, Iran
School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, 2007, Australia
Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran
Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA 6150, Australia
School of Engineering, Macquarie University, Sydney, New South Wales, 2109, Australia

1 These authors contributed equally to this article.

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Abstract

This review explores glucose monitoring and management strategies, emphasizing the need for reliable and user-friendly wearable sensors that are the next generation of sensors for continuous glucose detection. In addition, examines key strategies for designing glucose sensors that are multi-functional, reliable, and cost-effective in a variety of contexts. The unique features of effective diabetes management technology are highlighted, with a focus on using nano/biosensor devices that can quickly and accurately detect glucose levels in the blood, improving patient treatment and control of potential diabetes-related infections. The potential of next-generation wearable and touch-sensitive nano biomedical sensor engineering designs for providing full control in assessing implantable, continuous glucose monitoring is also explored. The challenges of standardizing drug or insulin delivery doses, low-cost, real-time detection of increased blood sugar levels in diabetics, and early digital health awareness controls for the adverse effects of injectable medication are identified as unmet needs. Also, the market for biosensors is expected to expand significantly due to the rising need for portable diagnostic equipment and an ever-increasing diabetic population. The paper concludes by emphasizing the need for further research and development of glucose biosensors to meet the stringent requirements for sensitivity and specificity imposed by clinical diagnostics while being cost-effective, stable, and durable.

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Nano Materials Science
Pages 263-283
Cite this article:
Safarkhani M, Aldhaher A, Heidari G, et al. Nanomaterial-assisted wearable glucose biosensors for noninvasive real-time monitoring: Pioneering point-of-care and beyond. Nano Materials Science, 2024, 6(3): 263-283. https://doi.org/10.1016/j.nanoms.2023.11.009

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Received: 22 September 2023
Accepted: 23 November 2023
Published: 15 December 2023
© 2023 Chongqing University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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