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Review | Open Access

Expert consensus on regenerative endodontic procedures

Xi Wei1, Maobin Yang2, Lin Yue3, Dingming Huang4, Xuedong Zhou4, Xiaoyan Wang3, Qi Zhang5, Lihong Qiu6, Zhengwei Huang7, Hanguo Wang8, Liuyan Meng9, Hong Li10, Wenxia Chen11, Xiaoying Zou3, Junqi Ling1( )
Department of Operative Dentistry and Endodontics, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, China
Department of Endodontology, Maurice H Kornberg School of Dentistry, Temple University, Philadelphia, Pennsylvania, USA
Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China
State Key Laboratory of Oral Diseases & Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, National Center of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu, China
Department of Endodontics, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China
Department of Endodontics, School of Stomatology, China Medical University, Shenyang, Liaoning, China
Department of Endodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Clinical Research Center for Oral Diseases; National Center for Stomatology; Shanghai Key Laboratory of Stomatology, Shanghai, China
Department of Operative Dentistry & Endodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, China
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China
Department of Endodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China
College of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China
Show Author Information

Abstract

Regenerative endodontic procedures (REPs) is a biologic-based treatment modality for immature permanent teeth diagnosed with pulp necrosis. The ultimate objective of REPs is to regenerate the pulp-dentin complex, extend the tooth longevity and restore the normal function. Scientific evidence has demonstrated the efficacy of REPs in promotion of root development through case reports, case series, cohort studies, and randomized controlled studies. However, variations in clinical protocols for REPs exist due to the empirical nature of the original protocols and rapid advancements in the research field of regenerative endodontics. The heterogeneity in protocols may cause confusion among dental practitioners, thus guidelines and considerations of REPs should be explicated. This expert consensus mainly discusses the biological foundation, the available clinical protocols and current status of REPs in treating immature teeth with pulp necrosis, as well as the main complications of this treatment, aiming at refining the clinical management of REPs in accordance with the progress of basic researches and clinical studies, suggesting REPs may become a more consistently evidence-based option in dental treatment.

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International Journal of Oral Science
Volume 14,
2022
Article number: 55
DOI: 10.1038/s41368-022-00206-z
Cite this article:
Wei X, Yang M, Yue L, et al. Expert consensus on regenerative endodontic procedures. International Journal of Oral Science, 2022, 14: 55. https://doi.org/10.1038/s41368-022-00206-z

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Accepted: 09 October 2022
Published: 01 December 2022
© The Author(s) 2023

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