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Review | Open Access

Mechanisms of bone pain: Progress in research from bench to bedside

Gehua Zhen1, Yuhan Fu1, Chi Zhang2, Neil C. Ford2, Xiaojun Wu3, Qichao Wu2, Dong Yan4, Xueming Chen5, Xu Cao1( ), Yun Guan2,6 ( )
Department of Orthopedics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
Division of Pathology, Sibley Memorial Hospital Washington, Washington, DC 20016, USA
Department of Oncology, Beijing Luhe Hospital, Capital Medical University, Beijing 100149, China
Department of Orthopedics, Beijing Luhe Hospital, Capital Medical University, Beijing 100149, China
Department of Neurological Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
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Abstract

The field of research on pain originating from various bone diseases is expanding rapidly, with new mechanisms and targets asserting both peripheral and central sites of action. The scope of research is broadening from bone biology to neuroscience, neuroendocrinology, and immunology. In particular, the roles of primary sensory neurons and non-neuronal cells in the peripheral tissues as important targets for bone pain treatment are under extensive investigation in both pre-clinical and clinical settings. An understanding of the peripheral mechanisms underlying pain conditions associated with various bone diseases will aid in the appropriate application and development of optimal strategies for not only managing bone pain symptoms but also improving bone repairing and remodeling, which potentially cures the underlying etiology for long-term functional recovery. In this review, we focus on advances in important preclinical studies of significant bone pain conditions in the past 5 years that indicated new peripheral neuronal and non-neuronal mechanisms, novel targets for potential clinical interventions, and future directions of research.

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Bone Research
Volume 10,
December 2022
Article number: 44
DOI: 10.1038/s41413-022-00217-w
Cite this article:
Zhen G, Fu Y, Zhang C, et al. Mechanisms of bone pain: Progress in research from bench to bedside. Bone Research, 2022, 10: 44. https://doi.org/10.1038/s41413-022-00217-w

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Received: 12 April 2022
Revised: 29 April 2022
Accepted: 09 May 2022
Published: 06 June 2022
© The Author(s) 2022

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