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Review | Open Access

The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

Hengwei Zhang1,2( ), Jane L. Liesveld3,4, Laura M. Calvi3,5, Brea C. Lipe3,4, Lianping Xing1,2, Michael W. Becker3,4, Edward M. Schwarz1,2,6,7,8, Shu-Chi A. Yeh1,6,8,9 ( )
Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Ave, Box 665, Rochester, NY 14642, USA
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA
Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
Department of Medicine, Division of Hematology/Oncology and Bone Marrow Transplantation Program, University of Rochester Medical Center, Rochester, NY, USA
Department of Medicine, Division of Endocrinology/Metabolism, University of Rochester Medical Center, Rochester, NY, USA
Department of Orthopaedics, University of Rochester Medical Center, Rochester, NY, USA
Department of Medicine, Division of Allergy/Immunology/Rheumatology, University of Rochester Medical Center, Rochester, NY, USA
Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA
Department of Physiology/Pharmacology, University of Rochester Medical Center, Rochester, NY, USA
Show Author Information

Abstract

Prior research establishing that bone interacts in coordination with the bone marrow microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell populations. Recent advances in intravital imaging has suggested that the expansion of hematopoietic stem cells (HSCs) and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone remodeling. These findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses. A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel interventions. To advance this understanding, herein, we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic compartment. Specifically, we elaborate on the coupling between bone remodeling and the BMME in homeostasis and age-related hematological malignancies and after treatment with bone-targeting approaches. We then discuss unresolved questions and ambiguities that remain in the field.

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Bone Research
Volume 11,
December 2023
Article number: 15
DOI: 10.1038/s41413-023-00249-w
Cite this article:
Zhang H, Liesveld JL, Calvi LM, et al. The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies. Bone Research, 2023, 11: 15. https://doi.org/10.1038/s41413-023-00249-w

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Received: 01 August 2022
Revised: 24 December 2022
Accepted: 26 January 2023
Published: 14 March 2023
© The Author(s) 2023

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