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Original Article | Open Access

Glucose uptake and distribution across the human skeleton using state-of-the-art total-body PET/CT

Weizhao Lu1, Yanhua Duan2, Kun Li2, Jianfeng Qiu1( ), Zhaoping Cheng2( )
Department of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, China
Department of PET-CT, the First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital Affiliated with Shandong University, Jinan 250014, China
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Abstract

A growing number of studies have demonstrated that the skeleton is an endocrine organ that is involved in glucose metabolism and plays a significant role in human glucose homeostasis. However, there is still a limited understanding of the in vivo glucose uptake and distribution across the human skeleton. To address this issue, we aimed to elucidate the detailed profile of glucose uptake across the skeleton using a total-body positron emission tomography (PET) scanner. A total of 41 healthy participants were recruited. Two of them received a 1-hour dynamic total-body 18F-fluorodeoxyglucose (18F-FDG) PET scan, and all of them received a 10-minute static total-body 18F-FDG PET scan. The net influx rate (Ki) and standardized uptake value normalized by lean body mass (SUL) were calculated as indicators of glucose uptake from the dynamic and static PET data, respectively. The results showed that the vertebrae, hip bone and skull had relatively high Ki and SUL values compared with metabolic organs such as the liver. Both the Ki and SUL were higher in the epiphyseal, metaphyseal and cortical regions of long bones. Moreover, trends associated with age and overweight with glucose uptake (SULmax and SULmean) in bones were uncovered. Overall, these results indicate that the skeleton is a site with significant glucose uptake, and skeletal glucose uptake can be affected by age and dysregulated metabolism.

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Bone Research
Volume 11,
December 2023
Article number: 36
DOI: 10.1038/s41413-023-00268-7
Cite this article:
Lu W, Duan Y, Li K, et al. Glucose uptake and distribution across the human skeleton using state-of-the-art total-body PET/CT. Bone Research, 2023, 11: 36. https://doi.org/10.1038/s41413-023-00268-7

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Received: 29 December 2022
Revised: 25 March 2023
Accepted: 12 May 2023
Published: 06 July 2023
© The Author(s) 2023

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