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Invited Article | Open Access

Species-level assessment of secondary metabolite diversity among Hamigera species and a taxonomic note on the genus

Yasuhiro Igarashia( ), Tomoaki Hanafusaa, Fumiya Gohdaa, Stephen Petersonb, Gerald Billsc
Department of Biotechnology and Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan
US Department of Agriculture, National Center for Agricultural Utilization Research, 1815 North University Street, Peoria, IL 61604, USA
Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1881 East Road, Houston, TX 77054, USA
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Abstract

Secondary metabolite phenotypes in nine species of the Hamigera clade were analysed to assess their correlations to a multi-gene species-level phylogeny. High-pressure-liquid-chromatography-based chemical analysis revealed three distinctive patterns of secondary metabolite production: (1) the nine species could be divided into two groups on the basis of production of the sesquiterpene tricinonoic acid; (2) the tricinonoic acid-producing group produced two cyclic peptides avellanins A and B; (3) the tricinonoic acid-non-producing group could be further divided into two groups according to the production of avellanins A and B. The chemical phenotype was consistent with the phylogeny of the species, although metabolite patterns were not diagnostic at the species level. In addition, the taxonomy of the Hamigera clade was updated with the new combination Hamigera ingelheimensis proposed for Merimbla ingelheimensis, so that all species in the clade are now in the same genus.

Keywords

phylogenydiversitysecondary metabolitechemotaxonomyHamigera ingelheimensisAspergillaceaeEurotiomycetes

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Mycology
Volume 5 Issue 3,
September 2014
Pages 102-109
DOI: 10.1080/21501203.2014.917736
Cite this article:
Igarashi Y, Hanafusa T, Gohda F, et al. Species-level assessment of secondary metabolite diversity among Hamigera species and a taxonomic note on the genus. Mycology, 2014, 5(3): 102-109. https://doi.org/10.1080/21501203.2014.917736

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Received: 06 February 2014
Accepted: 27 March 2014
Published: 22 July 2014
© 2014 The Author(s).

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
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