AI Chat Paper
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Search articles, authors, keywords, DOl and etc.
{{expandStatus?'Exit ':''}}Advanced Search
Adsorptive polymeric resins have been occasionally described to enhance the production of specific secondary metabolites (SMs) of interest. Methods that induce the expression of new chemical entities in fungal fermentations may lead to the discovery of new bioactive molecules and should be addressed as possible tools for the creation of new microbial chemical libraries for drug lead discovery. Herein, we apply both biological activity and chemical evaluations to assess the use of adsorptive resins as tools for the differential expression of SMs in fungal strain sets. Data automation approaches were applied to ultra high performance liquid chromatography analysis of extracts to evaluate the general influence in generating new chemical entities or in changing the production of specific SMs by fungi grown in the presence of resins and different base media.
Bergmann S, Schümann J, Scherlach K, Lange C, Brakhage AA, Hertweck C. 2007. Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol. 3:213–217. doi:10.1038/nchembio869
Bills G, Martin J, Collado J, Platas G, Overy D, Tormo JR, Vicente F, Verkleij GJM, Crous PW. 2009. Measuring the distribution and diversity of antibiosis and secondary metabolites in filamentous fungi. SIM News. 59:133–147.
Bills G, Platas G, Fillola A, Jiménez MR, Collado J, Vicente F, Martín J, González A, Bur-Zimmermann J, Tormo JR, Peláez F. 2008. Enhancement of antibiotic and secondary metabolite detection from filamentous fungi by growth on nutritional arrays. J Appl Microbiol. 104:1644–1658. doi:10.1111/j.1365-2672.2008.03735.x
Brakhage AA, Schroeckh V. 2011. Fungal secondary metabolites – strategies to activate silent gene clusters. Fungal Genet Biol. 48:15–22. doi:10.1016/j.fgb.2010.04.004
Combès A, Ndoye I, Bance C, Bruzaud J, Djediat C, Dupont J, Nay B, Prado S, Chaturvedi V. 2012. Chemical communication between the endophytic fungus Paraconiothyrium variabile and the phytopathogen Fusarium oxysporum. PLoS One. 7:e47313. doi:10.1371/journal.pone.0047313
de la Cruz M, Martín J, González-Menéndez V, Pérez-Victoria I, Moreno C, Tormo JR, El Aouad N, Guarro J, Vicente F, Reyes F, Bills GF. 2012. Chemical and physical modulation of antibiotic activity in Emericella species. Chem Biodivers. 9:1095–1113. doi:10.1002/cbdv.201100362
de Pedro N, Cautain B, Melguizo A, Vicente F, Genilloud O, Peláez F, Tormo JR. 2013. Mitochondrial Complex Ⅰ inhibitors, acetogenins, induce HepG2 cell death through the induction of the complete Ⅵ apoptotic mitochondrial pathway. J Bioenerg Biomembr. 45:153–164. doi:10.1007/s10863-012-9489-1
Dice LR. 1945. Measures of the amount of ecologic association between species. Ecology. 26:297–302. doi:10.2307/1932409.
Frykman S, Tsuruta H, Galazzo J, Licari P. 2006. Characterization of product capture resin during microbial cultivations. Ind Microbiol Biotechnol. 33:445–453. doi:10.1007/s10295-006-0088-1
García JB, Tormo JR. 2003. HPLC-studio: a novel software utility to perform HPLC chromatogram comparison for screening purposes. J Biomol Screen. 8:305–315. doi:10.1177/1087057103008003008
Gerth K, Washausen P, Höfle G, Irschik H, Reichenbach H. 1996. The jerangolids: a family of new antifungal compounds from Sorangium cellulosum (myxobacteria). Production, physico-chemical and biological properties of jerangolid A. J Antibiot. 49:71–75. doi:10.7164/antibiotics.49.71
Gross H. 2007. Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future prospects. Appl Microbiol Biotechnol. 75:267–277. doi:10.1007/s00253-007-0900-5
Hornung A, Bertazzo M, Dziarnowski A, Schneider K, Welzel K, Wohlert SE, Holzenkämpfer M, Nicholson GJ, Bechthold A, Süssmuth RD, et al. 2007. A genomic screening approach to the structure-guided identification of drug candidates from natural sources. ChemBioChem. 8:757–766. doi:10.1002/cbic.200600375
Igarashi Y, Iida T, Oku N, Watanabe H, Furihata K, Miyanouchi K. 2012. Nomimicin, a new spirotetronate-class polyketide from an actinomycete of the genus Actinomadura. J Antibiot. 65:355–359. doi:10.1038/ja.2012.30
Marshall VP, McWethy JS, Sirotti JM, Cialdella JI. 1990. The effect of neutral resins on the fermentation production of rubradirin. J Ind Microbiol. 5:283–287. doi:10.1007/BF01578202
Marshall VP, McWethy JS, Visser J, Cialdella JI, Laborde AL. 1987. Current fermentation technology from actinomycetes: the example of paulomycin. Dev Ind Microbiol. 28:105–114.
Monteiro MC, Dela Cruz M, Cantizani J, Moreno C, Tormo JR, Mellado E, De Lucas JR, Asensio F, Valiante V, Brakhage AA, et al. 2012. A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin. J Biomol Screen. 17:542–549. doi:10.1177/1087057111433459
Phillips T, Chase M, Wagner S, Renzi C, Powell M, DeAngelo J, Michels P. 2013. Use of in situ solid-phase adsorption in microbial natural product fermentation development. J Ind Microbiol Biotechnol. 40:411–425. doi:10.1007/s10295-013-1247-9
Singh MP, Leighton MM, Barbieri LR, Roll DM, Urbance SE, Hoshan L, McDonald LA. 2010. Fermentative production of self-toxic fungal secondary metabolites. J Ind Microbiol Biotechnol. 37:335–340. doi:10.1007/s10295-009-0678-9
Tormo JR, García JB, De Antonio M, Feliz J, Mira A, Díez MT, Hernández P, Peláez F. 2003. A method for the selection of production media for actinomycete strains based on their metabolite HPLC profiles. J Ind Microbiol Biotechnol. 30:582–588. doi:10.1007/s10295-003-0084-7
Warr GA, Veitch JA, Walsh AW, Hesler GA, Pirnik DM, Leet JE, Lin PM, Medina IA, McBrien KD, Forenza S, et al. 1996. BMS-182123, a fungal metabolite that inhibits the production of TNF-α. by macrophages and monocytes. J Antibiot. 49:234–240. doi:10.7164/antibiotics.49.234
Woo EJ, Starks CM, Carney JR, Arslanian R, Cadapan L, Zavala S, Licari P. 2002. Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis. J Antibiot. 55:141–146. doi:10.7164/antibiotics.55.141
Yarbrough GG, Taylor DP, Rowlands RT, Crawford MS, Lasure LL. 1993. Screening microbial metabolites for new drugs – theoretical and practical issues. J Antibiot. 46:535–544. doi:10.7164/antibiotics.46.535
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
京公网安备11010802044758号