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Review | Open Access

Plant associated fungal endophytes as a source of natural bioactive compounds

Nilesh Raia, Priyanka Kumari Keshria, Ashish Vermaa, Swapnil C. Kambleb, Pradeep Mishrac, Suvakanta Barikd, Santosh Kumar Singha, Vibhav Gautama ( )
Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Department of Technology, Savitribai Phule Pune University, Ganeshkhind, Pune, India
Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Chemical Engineering Discipline, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat, India
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Abstract

Endophytes are a potent source of bioactive compounds that mimic plant-based metabolites. The relationship of host plant and endophyte is significantly associated with alteration in fungal colonisation and the extraction of endophyte-derived bioactive compounds. Screening of fungal endophytes and their relationship with host plants is essential for the isolation of bioactive compounds. Numerous bioactive compounds with antioxidant, antimicrobial, anticancer, and immunomodulatory properties are known to be derived from fungal endophytes. Bioinformatics tools along with the latest techniques such as metabolomics, next-generation sequencing, and metagenomics multilocus sequence typing can potentially fill the gaps in fungal endophyte research. The current review article focuses on bioactive compounds derived from plant-associated fungal endophytes and their pharmacological importance. We conclude with the challenges and opportunities in the research area of fungal endophytes.

Keywords

biological activitybioactive compoundFungal endophytehost endophytes relationship

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Mycology
Volume 12 Issue 3,
September 2021
Pages 139-159
DOI: 10.1080/21501203.2020.1870579
Cite this article:
Rai N, Keshri PK, Verma A, et al. Plant associated fungal endophytes as a source of natural bioactive compounds. Mycology, 2021, 12(3): 139-159. https://doi.org/10.1080/21501203.2020.1870579

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Received: 07 October 2020
Accepted: 27 December 2020
Published: 27 January 2021
© 2021 The Author(s).

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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