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Research Article | Open Access

A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China

Jian Binga,#, Sijia Wanga,#, Heping Xub, Shuru Fana, Han Dua,c, Clarissa J. Nobiled,e, Guanghua Huanga ( )
Department of Infectious Diseases, Huashan Hospital and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
Department of Clinical Laboratory, First Affiliated Hospital of Xiamen University, Xiamen, China
Institutes of Biomedical Sciences, Fudan University, Shanghai, China
Department of Molecular and Cell Biology, University of California, Merced, CA, USA
Health Sciences Research Institute, University of California, Merced, CA, USA

#These authors contributed equally to this work.

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Abstract

The recently emerged fungal pathogen Candida auris often displays resistance to one or more antifungal drugs. Its infections have been identified in at least 40 countries on six continents to date. Here we report a case of C. auris candidemia in a patient in Xiamen, a city in south China. We also review currently reported cases of C. auris infection in China and compare the genetic and biological features of C. auris strains isolated from this country. Our phylogenetic analysis indicates that there are at least two C. auris genetic clades present in China (the South African clade and the south Asian clade) that display opposite mating type loci (one is MTLa and the other is MTLα). We also found that there are several distinct features among the clinical isolates studied, including the expression of virulence factors, antifungal susceptibilities, and cellular morphologies, and that these features could be associated with the mating-type of the isolate. For example, C. auris MTLa isolates generally secreted higher levels of secreted aspartyl proteases (Saps) at ambient environmental temperatures. Taken together, this study demonstrates that C. auris clinical isolates from China exhibit diversity in both biological and genetic features.

Keywords

morphologyvirulenceCandida aurisantifungal resistancemating type locus

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Mycology
Volume 13 Issue 1,
March 2022
Pages 68-75
DOI: 10.1080/21501203.2021.1994479
Cite this article:
Bing J, Wang S, Xu H, et al. A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China. Mycology, 2022, 13(1): 68-75. https://doi.org/10.1080/21501203.2021.1994479

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Received: 30 September 2021
Accepted: 12 October 2021
Published: 31 October 2021
© 2021 The Author(s).

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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