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Review | Open Access

Therapeutic properties of Inonotus obliquus (Chaga mushroom): A review

Phoebe Tee Yon Erna, Tang Yin Quana, Fung Shin Yeeb, Adeline Chia Yoke Yina( )
School of Biosciences, Faculty of Health & Medical Sciences, Taylor’s University, Subang Jaya, Selangor, Malaysia
Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, Kuala Lumpur, Malaysia
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Graphical Abstract

Abstract

Inonotus obliquus, also known as Chaga, is a medicinal mushroom that has been used for therapeutic purposes since the sixteenth century. Collections of folk medicine record the application of Chaga for the treatment of diseases such as gastrointestinal cancer, diabetes, bacterial infection, and liver diseases. Modern research provides scientific evidence of the therapeutic properties of I. obliquus extracts, including anti-inflammatory, antioxidant, anticancer, anti-diabetic, anti-obesity, hepatoprotective, renoprotective, anti-fatigue, antibacterial, and antiviral activities. Various bioactive compounds, including polysaccharides, triterpenoids, polyphenols, and lignin metabolites have been found to be responsible for the health-benefiting properties of I. obliquus. Furthermore, some studies have elucidated the underlying mechanisms of the mushroom’s medicinal effects, revealing the compounds’ interactions with enzymes or proteins of important pathways. Thus, this review aims to explore available information on the therapeutic potentials of Inonotus obliquus for the development of an effective naturally sourced treatment option.

Keywords

anti-inflammatoryanticanceranti-diabeticMedicinal mushroomInonotus obliquustherapeutic properties

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Mycology
Volume 15 Issue 2,
June 2024
Pages 144-161
DOI: 10.1080/21501203.2023.2260408
Cite this article:
Ern PTY, Quan TY, Yee FS, et al. Therapeutic properties of Inonotus obliquus (Chaga mushroom): A review. Mycology, 2024, 15(2): 144-161. https://doi.org/10.1080/21501203.2023.2260408

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Received: 24 July 2023
Accepted: 13 September 2023
Published: 20 October 2023
© 2023 The Author(s).

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
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