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Topical Review | Open Access

Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair

Juqing Song1Baiheng Lv1Wencong Chen1Peng Ding2( )Yong He3 ( )
School of Mechanical Engineering, Dongguan University of Technology, Dongguan 523808, People’s Republic of China
China Nuclear Power Technology Research Institute Co., Ltd, Shenzhen 518000, People’s Republic of China
School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, People’s Republic of China
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Abstract

Because of the complex nerve anatomy and limited regeneration ability of natural tissue, the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury (SCI) repair is not satisfactory. As an alternative method, tissue engineering is a promising method to regenerate peripheral nerve and spinal cord, and can provide structures and functions similar to natural tissues through scaffold materials and seed cells. Recently, the rapid development of 3D printing technology enables researchers to create novel 3D constructs with sophisticated structures and diverse functions to achieve high bionics of structures and functions. In this review, we first outlined the anatomy of peripheral nerve and spinal cord, as well as the current treatment strategies for the peripheral nerve injury and SCI in clinical. After that, the design considerations of peripheral nerve and spinal cord tissue engineering were discussed, and various 3D printing technologies applicable to neural tissue engineering were elaborated, including inkjet, extrusion-based, stereolithography, projection-based, and emerging printing technologies. Finally, we focused on the application of 3D printing technology in peripheral nerve regeneration and spinal cord repair, as well as the challenges and prospects in this research field.

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International Journal of Extreme Manufacturing
Article number: 032008
Cite this article:
Song J, Lv B, Chen W, et al. Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair. International Journal of Extreme Manufacturing, 2023, 5(3): 032008. https://doi.org/10.1088/2631-7990/acde21

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Received: 31 December 2022
Revised: 31 March 2023
Accepted: 12 June 2023
Published: 29 June 2023
© 2023 The Author(s).

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