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Review | Open Access

Multilayered regulation of secondary metabolism in medicinal plants

Yan Zhao1,2,†, Guanze Liu1,†, Feng Yang3,†, Yanli Liang1,2,†, Qingqing Gao1,2, Chunfan Xiang1,2, Xia Li1,2, Run Yang1,2, Guanghui Zhang1,2, Huifeng Jiang4( ), Lei Yu5( ), Shengchao Yang1( )
Key Laboratory of Medicinal Plant Biology of Yunnan Province, National & Local Joint Engineering Research Center on Germplasms Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, 650201 Kunming, China
College of Agronomy & Biotechnology, Yunnan Agricultural University, Kunming 650201, China
Institute of Chinese Medicinal Materials, Nanjing Agricultural University, Nanjing 210095, China
Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China
College of Agronomy, Yunnan Urban Agricultural Engineering and Technological Research Center, Kunming University, Kunming 650214, China

†Yan Zhao, Guanze Liu, Feng Yang and Yanli Liang contributed equally to this work.

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Abstract

Medicinal plants represent a huge reservoir of secondary metabolites (SMs), substances with significant pharmaceutical and industrial potential. However, obtaining secondary metabolites remains a challenge due to their low-yield accumulation in medicinal plants; moreover, these secondary metabolites are produced through tightly coordinated pathways involving many spatiotemporally and environmentally regulated steps. The first regulatory layer involves a complex network of transcription factors; a second, more recently discovered layer of complexity in the regulation of SMs is epigenetic modification, such as DNA methylation, histone modification and small RNA-based mechanisms, which can jointly or separately influence secondary metabolites by regulating gene expression. Here, we summarize the findings in the fields of genetic and epigenetic regulation with a special emphasis on SMs in medicinal plants, providing a new perspective on the multiple layers of regulation of gene expression.

Keywords

Transcription factorsMedicinal plantsEpigenetic regulationSecondary metabolismMultilayered regulation

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Molecular Horticulture
Volume 3 Issue 2,
June 2023
Pages 11-11
DOI: 10.1186/s43897-023-00059-y
Cite this article:
Zhao Y, Liu G, Yang F, et al. Multilayered regulation of secondary metabolism in medicinal plants. Molecular Horticulture, 2023, 3(2): 11. https://doi.org/10.1186/s43897-023-00059-y

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Received: 28 March 2023
Accepted: 27 April 2023
Published: 06 June 2023
© The Author(s) 2023.

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