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Research Article | Open Access

Preparation of Chitosan-based Microspheres for Rapid Hemostasis

Yan Fang( ), Peiyuan Li, Weikang Zhou
Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian Province, 350007, China
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Abstract

Rapid control of heavy hemorrhaging is critical to save the life of injured individuals. Herein, we developed a novel hemostat employing chitosan-based microspheres, which was prepared by sequential microemulsion of chitosan solution, sol-gel phase transition, and surface modification by 3, 4-dihydroxyhydrocinnamic acid (HCA). HCA-modified chitosan microspheres (CSMS-HCA) displayed a porous structure, with a high specific surface area (~211.3 m2/g), accelerating their rapid absorption of blood and concentrating red cells and platelets. The CSMS-HCA exhibited much better in vitro and in vivo hemostatic efficacy than porous chitosan microspheres did. Such a rapid hemostat in the form of microspheres is highly effective in treating deep and irregular wounds, owing to easy accessibility to injured sites.

Keywords

chitosanmicrosphereshemostasiswet-tissue adhesion

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Paper and Biomaterials
Volume 6 Issue 1,
January 2021
Pages 41-49
DOI: 10.12103/j.issn.2096-2355.2021.01.005
Cite this article:
Fang Y, Li P, Zhou W. Preparation of Chitosan-based Microspheres for Rapid Hemostasis. Paper and Biomaterials, 2021, 6(1): 41-49. https://doi.org/10.12103/j.issn.2096-2355.2021.01.005

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Received: 17 November 2020
Accepted: 16 December 2020
Published: 25 January 2021
© 2021 Paper and Biomaterials

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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