PDF (5.3 MB)
Collect
Submit Manuscript
Show Outline
Outline
Abstract
Keywords
References
Show full outline
Hide outline

Research Progress on Chemical Compounds and Pharmacological Actions in Nymphaea Genus

Shuang XIAO1Yining XU1Kaihang WANG1Changying HE1Jiangnan GENG1Jing MIAO2()Jinyao LI1
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, School of Life Science and Technology, Xinjiang University, Urumqi Xinjiang 830017, China
School of Pharmaceutical Sciences, Xinjiang University, Urumqi Xinjiang 830017, China
Show Author Information

Abstract

Nymphaea, which belongs to the family Nymphaeaceae, is widespread and includes a large number of species with a beautiful appearance, and are often cultivated as ornamental plants. With the in-depth study of Nymphaea, it is found that Nymphaea not only have a history of traditional uses such as ornamental, edible and tea-making, but also have high medicinal value and potential for drug research and development. Its phytochemical research found that Nymphaea is rich in composition, mainly containing flavonoids and polyphenols and their derivatives, followed by volatile components, organic acids, alkaloids and other components, with antibacterial, anti-inflammatory, antioxidant, anti-tumor, neuroprotective, hypoglycaemic, hepatoprotective and other pharmacological effects, the flavonoids and polyphenols play an important role in the efficacy of the components. A review of previous studies was conducted to summarize the chemical constituents and pharmacological activities of Nymphaea plants. This review was conducted to provide a reference for further research on Nymphaea plants and to elucidate the material basis for subsequent pharmacological research.

CLC number: R284;R285 Document code: A Article ID: 2096-7675(2025)01-0082-017

References

[1]
LIU X R, LI L, ZHOU D Q. Resources and cultivation applications of water lilies[J]. Xiandai Horticulture, 2022(12): 156-158. (in Chinese)
[2]
ZHANG H P, FANG W M, CHEN F D, et al. Investigation on the morphological diversity of taxa in genus Nymphaea[J]. Journal of Nanjing Agricultural University, 2009, 32(4): 47-52. (in Chinese)
[3]
LA-ONGSRI W, TRISONTHI C, BALSLEV H. A synopsis of Thai Nymphaeaceae[J]. Nordic Journal of Botany, 2009, 27(2): 97-114.
[4]
LIU R N, WANG W, DING Y, et al. A new flavonol glycoside and activity of compounds from the flower of Nymphaea candida[J]. Journal of Asian Natural Products Research, 2007, 9(3/4/5): 333-338.
[5]
ZHAO J, YAN M, HE J H, et al. Flavonol glycosides from the flowers of Nymphaea candida[J]. Chinese Journal of Modern Applied Pharmacy, 2008, 25(2): 115-117. (in Chinese)
[6]
AGNIHOTRI V K, ELSOHLY H N, KHAN S I, et al. Antioxidant constituents of Nymphaea caerulea flowers[J]. Phytochemistry, 2008, 69(10): 2061-2066.
[7]
YU F M, XU S M, ZHANG Z W, et al. Advances in study on chemical constituents and pharmacological activities of Nymphaea hybrida Peck[J]. Journal of Food Science and Biotechnology, 2021, 40(6): 18-24. (in Chinese)
[8]
TUNGMUNNITHUM D, DROUET S, KABRA A, et al. Enrichment in antioxidant flavonoids of stamen extracts from Nymphaea lotus L. using ultrasonic-assisted extraction and macroporous resin adsorption[J]. Antioxidants, 2020, 9(7): 576.
[9]
ZHANG Z Z, ELSOHLY H N, LI X C, et al. Phenolic compounds from Nymphaea odorata[J]. Journal of Natural Products, 2003, 66(4): 548-550.
[10]
ZHAO J, LIU T, MA L, et al. Antioxidant and preventive effects of extract from Nymphaea candida flower on in vitro immunological liver injury of rat primary hepatocyte cultures[J]. Evidence-Based Complementary and Alternative Medicine, 2011, 2011: 497673.
[11]
ZHAO J, XU F, JI T F, et al. Studies on phenolic compounds from buds of Nymphaea candida Presl[J]. Natural Product Research and Development, 2013, 25(7): 916-918. (in Chinese)
[12]
ELEGAMI A A, BATES C, GRAY A I, et al. Two very unusual macrocyclic flavonoids from the water lily Nymphaea lotus[J]. Phytochemistry, 2003, 63(6): 727-731.
[13]
ZHU M L, ZHENG X C, SHU Q Y, et al. Relationship between the composition of flavonoids and flower colors variation in tropical water lily (Nymphaea) cultivars[J]. PLoS One, 2012, 7(4): e34335.
[14]
CUDALBEANU M, GHINEA I O, FURDUI B, et al. Exploring new antioxidant and mineral compounds from Nymphaea alba wild-grown in Danube delta biosphere[J]. Molecules, 2018, 23(6): 1247.
[15]
CHEN L M, ZULIPIYA T, YUSUFUJIANG A, et al. Establishment of a quality control method for simultaneous determination of multiple active components in Uygur medicine of Nymphaeae flos[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2023, 29(9): 202-209. (in Chinese)
[16]
ACHARYA J, DUTTA M, CHAUDHURY K, et al. Metabolomics and chemometric study for identification of acetylcholinesterase inhibitor(s) from the flower extracts of Nymphaea pubescens[J]. Journal of Food Biochemistry, 2018, 42(5): e12575.
[17]
GUO Y H, LIN F, HUANG S R, et al. Composition analysis of essential oil from flowers of Nymphaea stellata, a wild water lily in Hainan[J]. Chinese Journal of Tropical Agriculture, 2021, 41(8): 60-65. (in Chinese)
[18]
ZHOU Q, ZHAO F, ZHANG H H, et al. Optimization of test conditions and the study on volatile components in different parts of Nymphaea hybrid[J/OL]. Molecular Plant Breeding. https://kns.cnki.net/kcms/detail/46.1068.S.20220421.1642.025.html. (in Chinese)
[19]
SUBASH-BABU P, IGNACIMUTHU S, AGASTIAN P, et al. Partial regeneration of beta-cells in the islets of Langerhans by Nymphayol a sterol isolated from Nymphaea stellata (Willd.) flowers[J]. Bioorganic & Medicinal Chemistry, 2009, 17(7): 2864-2870.
[20]
VERMA A, AHMED B, UPADHYAY R, et al. Nymphasterol, a new steroid from Nymphaea stellata[J]. Medicinal Chemistry Research, 2012, 21(6): 783-787.
[21]
CHOWDHURY B N, HAQUE M M, SOHRAB M H, et al. Steroids from the stem of Nymphaea stellata[J]. Journal of Bangladesh Academy of Sciences, 2013, 37(1): 109-113.
[22]
LIU D D, LUO J, XIANG W W, et al. Antimicrobial and anti-inflammatory effects of crude extract of Nymphaea candida on major pathogens in cow mastitis in vitro[J]. Progress in Veterinary Medicine, 2021, 42(7): 17-21. (in Chinese)
[23]
BATOOL R, KALSOOM A, AKBAR I, et al. Antilisterial effect of Rosa damascena and Nymphaea alba in Mus musculus[J]. BioMed Research International, 2018, 2018: 4543723.
[24]
PARIMALA M, SHOBA F G. In vitro antimicrobial activity and HPTLC analysis of hydroalcoholic seed extract of Nymphaea nouchali Burm. f.[J]. BMC Complementary and Alternative Medicine, 2014, 14: 361.
[25]
DISSANAYAKE R K, RATNAWEERA P B, WILLIAMS D E, et al. Antimicrobial activities of endophytic fungi of the Sri Lankan aquatic plant Nymphaea nouchali and chaetoglobosin A and C, produced by the endophytic fungus Chaetomium globosum[J]. Mycology, 2016, 7(1): 1-8.
[26]
WANG S L. Progress on anti-inflammatory and analgesic effects of natural products[J]. Progress in Veterinary Medicine, 2013, 34(10): 106-110. (in Chinese)
[27]
REGE M G, AYANWUYI L O, ZEZI A U, et al. Anti-nociceptive, anti-inflammatory and possible mechanism of anti-nociceptive action of methanol leaf extract of Nymphaea lotus Linn (Nymphaeceae)[J]. Journal of Traditional and Complementary Medicine, 2021, 11(2): 123-129.
[28]
HSU C L, FANG S C, YEN G C. Anti-inflammatory effects of phenolic compounds isolated from the flowers of Nymphaea mexicana Zucc[J]. Food & Function, 2013, 4(8): 1216-1222.
[29]
ZHANG W, ZHU Y X, PENG F, et al. Effects of effective components of Nymphaea candida on antibacterial and anti-inflammatory activities of major pathogenic bacteria in cow mastitis[J]. Progress in Veterinary Medicine, 2022, 43(6): 63-68. (in Chinese)
[30]
LIU K, LUO M, WEI S. The bioprotective effects of polyphenols on metabolic syndrome against oxidative stress: Evidences and perspectives[J]. Oxidative Medicine and Cellular Longevity, 2019, 2019: 6713194.
[31]
N’GUESSAN B B, ASIAMAH A D, ARTHUR N K, et al. Ethanolic extract of Nymphaea lotus L. (Nymphaeaceae) leaves exhibits in vitro antioxidant, in vivo anti-inflammatory and cytotoxic activities on Jurkat and MCF-7 cancer cell lines[J]. BMC Complementary Medicine and Therapies, 2021, 21(1): 22.
[32]
MO X N, LI A, YU Q M, et al. Ultrasound extraction technology and antioxidant activity of polysaccharides from waterlily flower[J]. Grain Science and Technology and Economy, 2019, 44(4): 91-94. (in Chinese)
[33]
PARIMALA M, SHOBA F G. Phytochemical analysis and in vitro antioxidant acitivity of hydroalcoholic seed extract of Nymphaea nouchali Burm. f.[J]. Asian Pacific Journal of Tropical Biomedicine, 2013, 3(11): 887-895.
[34]
ALAM M, JU M K, LEE S H. DNA protecting activities of Nymphaea nouchali (Burm. f) flower extract attenuate t-BHP-induced oxidative stress cell death through Nrf2-mediated induction of heme oxygenase-1 expression by activating MAP-kinases[J]. International Journal of Molecular Sciences, 2017, 18(10): 2069.
[35]
AL-HARBI L N, SUBASH-BABU P, BINOBEAD M A, et al. Potential metabolite nymphayol isolated from water lily (Nymphaea stellata) flower inhibits MCF-7 human breast cancer cell growth via upregulation of Cdkn2a, pRb2, p53 and downregulation of PCNA mRNA expressions[J]. Metabolites, 2020, 10(7): 280.
[36]
AIMVIJARN P, PALIPOCH S, OKADA S, et al. Thai water lily extract induces B16 melanoma cell apoptosis and inhibits cellular invasion through the role of cellular oxidants[J]. Asian Pacific Journal of Cancer Prevention, 2018, 19(1): 149-153.
[37]
CUDALBEANU M, PEITINHO D, SILVA F, et al. Sono-biosynthesis and characterization of AuNPs from Danube delta Nymphaea alba root extracts and their biological properties[J]. Nanomaterials, 2021, 11(6): 1562.
[38]
LIU R N, WANG W, XIE W D, et al. Nymphaea candida flavonols: Antioxidation and ischemic injury effect on neurons[J]. World Science and Technology, 2006, 8(5): 33-36+29. (in Chinese)
[39]
HONG S Y, JEONG W S, JUN M. Protective effects of the key compounds isolated from Corni fructus against β-amyloid-induced neurotoxicity in PC12 cells[J]. Molecules, 2012, 17(9): 10831-10845.
[40]
KHAN H, ULLAH H, ASCHNER M, et al. Neuroprotective effects of quercetin in Alzheimer’s disease[J]. Biomolecules, 2019, 10(1): 59.
[41]
GUPTA A, SINGH A K, KUMAR R, et al. Neuroprotective potential of ellagic acid: A critical review[J]. Advances in Nutrition, 2021, 12(4): 1211-1238.
[42]
SUN X Y, LI L J, DONG Q X, et al. Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease[J]. Journal of Neuroinflammation, 2021, 18(1): 131.
[43]
YOUN K, JUN M. In vitro BACE1 inhibitory activity of geraniin and corilagin from Geranium thunbergii[J]. Planta Medica, 2013, 79(12): 1038-1042.
[44]
YANG M, HAO Z Y, ZHOU S Q, et al. Chemical constituents from fruits of Cornus officinalis and their anti-Alzheimer’s disease activity[J]. Acta Pharmaceutica Sinica, 2022, 57(12): 3608-3615. (in Chinese)
[45]
ISHRAT N, KHAN H, PATEL O P S, et al. Role of glycation in type 2 diabetes mellitus and its prevention through Nymphaea species[J]. BioMed Research International, 2021, 2021: 7240046.
[46]
DEBNATH S, GHOSH S, HAZRA B. Inhibitory effect of Nymphaea pubescens Willd. flower extract on carrageenan-induced inflammation and CCl4-induced hepatotoxicity in rats[J]. Food and Chemical Toxicology, 2013, 59: 485-491.
[47]
ZHAO J, ZHANG S L, YOU S P, et al. Hepatoprotective effects of nicotiflorin from Nymphaea candida against concanavalin A-induced and D-galactosamine-induced liver injury in mice[J]. International Journal of Molecular Sciences, 2017, 18(3): 587.
[48]
BAKR R O, EL-NAA M M, ZAGHLOUL S S, et al. Profile of bioactive compounds in Nymphaea alba L. leaves growing in Egypt: Hepatoprotective, antioxidant and anti-inflammatory activity[J]. BMC Complementary and Alternative Medicine, 2017, 17(1): 52.
[49]
LI Q, LI C Y, ZHAN Y J, et al. Inhibitory action of extracts from water lily flower on tyrosinase activity and its kinetics[J]. China Surfactant Detergent & Cosmetics, 2017, 47(4): 219-222. (in Chinese)
[50]
LIU H M, LEI S N, TANG W, et al. Optimization of ultrasound-assisted cellulase extraction from Nymphaea hybrid flower and biological activities: Antioxidant activity, protective effect against ROS oxidative damage in HaCaT cells and inhibition of melanin production in B16 cells[J]. Molecules, 2022, 27(6): 1914.
[51]
BELLO F H, MAIHA B B, ANUKA J A. The effect of methanol rhizome extract of Nymphaea lotus Linn. (Nymphaeaceae) in animal models of diarrhoea[J]. Journal of Ethnopharmacology, 2016, 190: 13-21.
[52]
FAJEMIROYE J O, ADAM K, JORDAN K Z, et al. Evaluation of anxiolytic and antidepressant-like activity of aqueous leaf extract of Nymphaea lotus Linn. in mice[J]. Iranian Journal of Pharmaceutical Research, 2018, 17(2): 613-626.
[53]
KAMENI P M, DZEUFIET D P D, BILANDA D C, et al. Nymphaea lotus Linn. (Nymphaeaceae) alleviates sexual disability in L-NAME hypertensive male rats[J]. Evidence-Based Complementary and Alternative Medicine, 2019, 2019: 8619283.
[54]
ANTONISAMY P, SUBASH-BABU P, ALSHATWI A A, et al. Gastroprotective effect of Nymphayol isolated from Nymphaea stellata (Willd.) flowers: Contribution of antioxidant, anti-inflammatory and anti-apoptotic activities[J]. Chemico-Biological Interactions, 2014, 224: 157-163.
[55]
CHENG J H, LEE S Y, LIEN Y Y, et al. Immunomodulating activity of Nymphaea rubra Roxb. extracts: Activation of rat dendritic cells and improvement of the TH1 immune response[J]. International Journal of Molecular Sciences, 2012, 13(9): 10722-10735.
Journal of Xinjiang University(Natural Science Edition in Chinese and English)
Pages 82-98
Cite this article:
XIAO S, XU Y, WANG K, et al. Research Progress on Chemical Compounds and Pharmacological Actions in Nymphaea Genus. Journal of Xinjiang University(Natural Science Edition in Chinese and English), 2025, 42(1): 82-98. https://doi.org/10.13568/j.cnki.651094.651316.2023.12.04.0001
Metrics & Citations  
Article History
Copyright
Return