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Research Article | Open Access

Biodegradable mineralized collagen plug for the reconstruction of craniotomy burr-holes: A report of three cases

Zhiye Qiu1,2, Yuqi Zhang3, Ziqiang Zhang2, Tianxi Song2, Fuzhai Cui1( )
School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
Beijing Allgens Medical Science and Technology Co., Ltd., Beijing 100176, China
Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing 100040, China
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Abstract

Objectives:

In this case report, we describe the design, fabrication and clinical outcomes of a novel bioresorbable, mineralized collagen burr-hole plug for the reconstruction of craniotomy burr-holes.

Methods:

Mineralized collagen burr-hole plugs were fabricated via a biomimetic mineralization process. The biomimetic mineralized collagen has a similar chemical composition and microstructure to natural bone tissue, thereby possessing good biocompatibility and osteoconductivity. The mineralized collagen burr-hole plugs were implanted into three patients, and clinical outcomes were evaluated at one-year follow-ups.

Results:

All bone defects healed very well using the mineralized collagen burr-hole plugs, and there were no adverse reactions at the surgical sites.

Conclusions:

The clinical outcomes indicated that the mineralized collagen was effective for reconstructing burr-holes in the skull after craniotomy.

Keywords

clinical observationmineralized collagenburr-hole plugbioresorbable

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Brain Science Advances
Volume 1 Issue 1,
September 2015
Pages 3-9
DOI: 10.18679/CN11-6030_R.2015.002
Cite this article:
Qiu Z, Zhang Y, Zhang Z, et al. Biodegradable mineralized collagen plug for the reconstruction of craniotomy burr-holes: A report of three cases. Brain Science Advances, 2015, 1(1): 3-9. https://doi.org/10.18679/CN11-6030_R.2015.002

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Received: 23 March 2015
Revised: 03 May 2015
Accepted: 14 May 2015
Published: 01 September 2015
© The authors 2015.

This article is published with open access at www.TNCjournal.com
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