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Original Article | Open Access

Malignant transformation and treatment of cystic mixed germ cell tumor

Yapeng Zhao1, Hongyu Duan2, Qinghui Zhang1,2, Bingxin Shi1, Hui Liang2, Yuqi Zhang1,2( )
The Medical Center, Tsinghua University, Beijing 100084, China
Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing 100040, China
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Abstract

Objective:

The authors report an extremely unusual presentation and management of a children pineal mixed germ cell tumor mainly composed of immature teratoma, aiming to summarize main theraptic points by literature review.

Methods:

A cystic lesion located in the rear of third ventricle in a child was detected 3 years ago with no other therapy performed except for a ventriculo-peritoneal shunt. During the following 3 years, intermitted regular brain MRI demonstrated no evidence of lesion aggrandizement. However from 20 days before admission to our institute the patient began to present acutely with exacerbating clinical symptoms meanwhile brain MRI showed signs of abrupt revulsions of initial lesion without any incentive cause. Neurological examination revealed a significant rising of serum tumor marker level. Then surgical resection was performed immediately after admission which was followed by correlative two-course chemotherapy.

Results:

Postoperative brain MRI demonstrated totally removing of the lesion in rear of third ventricle. Serum tumor marker level decreased remarkably after surgery and declined to normal level after two-course chemotherapy. No obvious neurological deficit occurred except for short-term memory difficulty which gradually recovered within two weeks. Soon after the second course chemotherapy the patient was currently asymptomatic and returned to school.

Conclusions:

(1) To ensure definitive diagnosis and proper therapecutic protocols benefit from grasping clinical features of mixed germ cell tumor. (2) Overall preoperative investigation including serum tumor marker level is as critical as neurological imaging examination. (3) Surgical excision is confirmed to be the key modality of treatment. With the regarding of mixed germ cell tumor, never highlight total resection too much. (4) Postoperative adjuvant chemotherapy is recommended as further intensive treatment to improve the prognosis of mix germ cell tumor.

Keywords

surgerychemotherapyprognosisgerm cell tumor

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Brain Science Advances
Volume 2 Issue 1,
March 2016
Pages 25-30
DOI: 10.18679/CN11-6030_R.2016.001
Cite this article:
Zhao Y, Duan H, Zhang Q, et al. Malignant transformation and treatment of cystic mixed germ cell tumor. Brain Science Advances, 2016, 2(1): 25-30. https://doi.org/10.18679/CN11-6030_R.2016.001

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Received: 03 December 2015
Revised: 25 December 2015
Accepted: 31 December 2015
Published: 01 March 2016
© The authors 2016.

This article is published with open access at www.TNCjournal.com
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