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Original Article | Open Access

Gangliocytoma combined with a pituitary adenoma: Reports of three cases and literature review

Zhenmin Wang1Peng Li1Qiangyi Zhou1Zhijun Yang1Pinan Liu1,2( )
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
Department of Neural Reconstruction, Beijing Neurosurgery Institute, Capital Medical University, Beijing 100050, China
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Abstract

Objectives:

Sellar gangliocytomas are extremely rare. Since they present clinically and radiologically as pituitary adenomas, the preoperative diagnosis of these mixed tumors is very difficult. Here, we report three cases of gangliocytoma combined with pituitary adenoma and describe our findings.

Methods:

The clinical data of the three cases of gangliocytoma combined with pituitary adenoma have been retrospectively analyzed, and the published literature has also been reviewed.

Results:

All three patients underwent pure endonasal endoscopic surgery, and no recurrence was observed over a follow-up of at least 30 months. Growth hormone (GH)-hypersecreting adenoma and tumor calcification were detected in these mixed tumors.

Conclusions:

Pure endoscopic transnasal transsphenoidal surgery may be an effective way for the treatment of this kind of tumor. Gross total resection of the tumor is recommended. In addition, calcification with GH-hypersecretion may serve as a preoperative diagnostic clue for gangliocytoma in the sella turcica.

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Brain Science Advances
Pages 165-171
Cite this article:
Wang Z, Li P, Zhou Q, et al. Gangliocytoma combined with a pituitary adenoma: Reports of three cases and literature review. Brain Science Advances, 2016, 2(3): 165-171. https://doi.org/10.18679/CN11-6030_R.2016.026

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Received: 20 July 2016
Revised: 18 July 2016
Accepted: 20 August 2016
Published: 01 September 2016
© The authors 2016.

This article is published with open access at www.TNCjournal.com

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