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Review | Open Access

CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value

Jie Wu,*Lan Li,*Siyi WuBin Xu ( )
Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China

*These authors contributed equally to this work.

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Abstract

The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.

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Cancer Biology & Medicine
Pages 528-542
Cite this article:
Wu J, Li L, Wu S, et al. CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value. Cancer Biology & Medicine, 2020, 17(3): 528-542. https://doi.org/10.20892/j.issn.2095-3941.2020.0032

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Received: 30 January 2020
Accepted: 08 June 2020
Published: 15 August 2020
©2020 Cancer Biology & Medicine.

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