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Review | Open Access

Zinc dysregulation in cancers and its potential as a therapeutic target

Jie Wang,*Huanhuan Zhao,*Zhelong XuXinxin Cheng ( )
Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China

*These authors contributed equally to the work.

Show Author Information

Abstract

Zinc is an essential element and serves as a structural or catalytic component in many proteins. Two families of transporters are involved in maintaining cellular zinc homeostasis: the ZIP (SLC39A) family that facilitates zinc influx into the cytoplasm, and the ZnT (SLC30A) family that facilitates zinc efflux from the cytoplasm. Zinc dyshomeostasis caused by the dysfunction of zinc transporters can contribute to the initiation or progression of various cancers, including prostate cancer, breast cancer, and pancreatic cancer. In addition, intracellular zinc fluctuations lead to the disturbance of certain signaling pathways involved in the malignant properties of cancer cells. This review briefly summarizes our current understanding of zinc dyshomeostasis in cancer, and discusses the potential roles of zinc or zinc transporters in cancer therapy.

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Cancer Biology & Medicine
Pages 612-625
Cite this article:
Wang J, Zhao H, Xu Z, et al. Zinc dysregulation in cancers and its potential as a therapeutic target. Cancer Biology & Medicine, 2020, 17(3): 612-625. https://doi.org/10.20892/j.issn.2095-3941.2020.0106

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Received: 12 March 2020
Accepted: 08 June 2020
Published: 15 August 2020
©2020 Cancer Biology & Medicine.

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