AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Cancer Biology & Medicine Article
PDF (636.8 KB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Review | Open Access

Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation

Chuanshi He1,*, Ling Li1,*, Linlin Wang1, Wanrong Meng1, Yaying Hao1, Guiquan Zhu2 ( )
Department of Stomatology, Sichuan Cancer Hospital, Sichuan Key Laboratory of Radiation Oncology, School of Medicine, University of Electronic Science and Technology of China
State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

*These authors contributed equally to this work.

Show Author Information

Abstract

Radiotherapy is one of the most effective treatment methods for various solid tumors. Bidirectional signal transduction between cancer cells and stromal cells within the irradiated microenvironment is important in cancer development and treatment responsiveness. Exosomes, initially considered as “garbage bins” for unwanted from cells, are now understood to perform a variety of functions in interactions within the tumor microenvironment. Exosome-mediated regulation processes are rebuilt under the irradiation stimuli, because the exosome production, uptake, and contents are markedly modified by irradiation. In turn, irradiation-modified exosomes may modulate the cell response to irradiation through feedback regulation. Here, we review current knowledge and discuss the roles of exosome-mediated interactions between cells under radiotherapy conditions.

Keywords

irradiationRadiotherapytumor microenvironmentextracellular vesicleexosome

References

1

Schaue D, Mcbride WH. Opportunities and challenges of radiotherapy for treating cancer. Nature Rev Clin Oncol. 2015; 12: 527-40.
Crossref Google Scholar
2

Bhide SA, Nutting CM. Recent advances in radiotherapy. BMC Med. 2010; 8: 25.
Crossref Google Scholar
3

Kunkler IH, Audisio R, Belkacemi Y, Betz M, Gore E, Hoffe S, et al. Review of current best practice and priorities for research in radiation oncology for elderly patients with cancer: the International Society of Geriatric Oncology (SIOG) task force. Ann Oncol. 2014; 25: 2134-46.
Crossref Google Scholar
4

Brix N, Tiefenthaller A, Anders H, Belka C, Lauber K. Abscopal, immunological effects of radiotherapy: narrowing the gap between clinical and preclinical experiences. Immun Rev. 2017; 280: 249-79.
Crossref Google Scholar
5

Chevalier F, Hamdi DH, Saintigny Y, Lefaix JL. Proteomic overview and perspectives of the radiation-induced bystander effects. Mutat Res Rev Mutat Res. 2015; 763: 280-93.
Crossref Google Scholar
6

Al-mayah A, Bright S, Chapman K, Irons S, Luo P, Carter D, et al. The non-targeted effects of radiation are perpetuated by exosomes. Mutat Res. 2015; 772: 38-45.
Crossref Google Scholar
7

Vermeer PD. Exosomal induction of tumor innervation. Cancer Res. 2019; 79: 3529-35.
Crossref Google Scholar
8

Thery C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018; 7: 1535750-83.
Crossref Google Scholar
9

Kalluri R, Lebleu VS. The biology, function, and biomedical applications of exosomes. Science (New York, NY). 2020; 367: eaau6977.
Crossref Google Scholar
10

Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9: 654-9.
Crossref Google Scholar
11

Thakur BK, Zhang H, Becker A, Matei I, Huang Y, Costa-Silva B, et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res. 2014; 24: 766-9.
Crossref Google Scholar
12

Cheng Q, Shi X, Han M, Smbatyan G, Lenz HJ, Zhang Y. Reprogramming exosomes as nanoscale controllers of cellular immunity. J Am Chem Soc. 2018; 140: 16413-7.
Crossref Google Scholar
13

He C, Zheng S, Luo Y, Wang B. Exosome theranostics: biology and translational medicine. Theranostics. 2018; 8: 237-55.
Crossref Google Scholar
14

Ruivo CF, Adem B, Silva M, Melo SA. The biology of cancer exosomes: insights and new perspectives. Cancer Res. 2017; 77: 6480-8.
Crossref Google Scholar
15

Luo A, Zhou X, Shi X, Zhao Y, Men Y, Chang X, et al. Exosomederived miR-339-5p mediates radiosensitivity by targeting Cdc25A in locally advanced esophageal squamous cell carcinoma. Oncogene. 2019; 38: 4990-5006.
Crossref Google Scholar
16

Ariyoshi K, Miura T, Kasai K, Fujishima Y, Nakata A, Yoshida M. Radiation-induced bystander effect is mediated by mitochondrial DNA in exosome-like vesicles. Sci Rep. 2019; 9: 9103.
Crossref Google Scholar
17

Johnstone RM, Adam M, Hammond JR, Orr L, Turbide C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem. 1987; 262: 9412-20.
Crossref Google Scholar
18

Harding C, Heuser J, Stahl P. Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding. Eur J Cell Biol. 1984; 35: 256-63.
Google Scholar
19

Van Niel G, D’angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018; 19: 213-28.
Crossref Google Scholar
20

Pan BT, Teng K, Wu C, Adam M, Johnstone RM. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol. 1985; 101: 942-8.
Crossref Google Scholar
21

Raposo G, Nijman HW, Stoorvogel W, Liejendekker R, Harding CV, Melief CJ, et al. B lymphocytes secrete antigen-presenting vesicles. J Exp Med. 1996; 183: 1161-72.
Crossref Google Scholar
22

Théry C, Zitvogel L, Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002; 2: 569-79.
Crossref Google Scholar
23

Mathieu M, Martin-Jaular L, Lavieu G, Théry C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019; 21: 9-17.
Crossref Google Scholar
24

Kowal J, Tkach M, Théry C. Biogenesis and secretion of exosomes. Curr Opin Cell Biol. 2014; 29: 116-25.
Crossref Google Scholar
25

Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013; 200: 373-83.
Crossref Google Scholar
26

Keerthikumar S, Chisanga D, Ariyaratne D, Al Saffar H, Anand S, Zhao K, et al. ExoCarta: a web-based compendium of exosomal cargo. J Mol Biol. 2016; 428: 688-92.
Crossref Google Scholar
27

Li S, Li Y, Chen B, Zhao J, Yu S, Tang Y, et al. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Res. 2018; 46(D1): D106-D12.
Crossref Google Scholar
28

Liu T, Zhang Q, Zhang J, Li C, Miao YR, Lei Q, et al. EVmiRNA: a database of miRNA profiling in extracellular vesicles. Nucleic Acids Res. 2019; 47: D89-93.
Crossref Google Scholar
29

Choi DS, Kim DK, Kim YK, Gho YS. Proteomics of extracellular vesicles: exosomes and ectosomes. Mass Spectrom Rev. 34: 474-90.
Crossref Google Scholar
30

Li W, Li C, Zhou T, Liu X, Liu X, Li X, et al. Role of exosomal proteins in cancer diagnosis. Mol Cancer. 2017; 16: 145.
Crossref Google Scholar
31

Wubbolts R, Leckie RS, Veenhuizen PT, Schwarzmann G, Mobius W, Hoernschemeyer J, et al. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J Biol Chem. 2003; 278: 10963-72.
Crossref Google Scholar
32

Bellingham SA, Coleman BM, Hill AF. Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells. Nucleic Acids Res. 2012; 40: 10937-49.
Crossref Google Scholar
33

Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science (New York, NY). 2008; 319: 1244-7.
Crossref Google Scholar
34

Maji S, Chaudhary P, Akopova I, Nguyen PM, Hare RJ, Gryczynski I, et al. Exosomal annexin Ⅱ promotes angiogenesis and breast cancer metastasis. Mol Cancer Res. 2017; 15: 93-105.
Crossref Google Scholar
35

Vicencio JM, Yellon DM, Sivaraman V, Das D, Boi-Doku C, Arjun S, et al. Plasma exosomes protect the myocardium from ischemiareperfusion injury. J Am Coll Cardiol. 2015; 65: 1525-36.
Crossref Google Scholar
36

Agarwal K, Saji M, Lazaroff SM, Palmer AF, Ringel MD, Paulaitis ME. Analysis of exosome release as a cellular response to MAPK pathway inhibition. Langmuir. 2015; 31: 5440-8.
Crossref Google Scholar
37

Yu X, Harris SL, Levine AJ. The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res. 2006; 66: 4795-801.
Crossref Google Scholar
38

Lespagnol A, Duflaut D, Beekman C, Blanc L, Fiucci G, Marine JC, et al. Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ. 2008; 15: 1723-33.
Crossref Google Scholar
39

Arscott WT, Tandle AT, Zhao S, Shabason JE, Gordon IK, Schlaff CD, et al. Ionizing radiation and glioblastoma exosomes: implications in tumor biology and cell migration. Translat Oncol. 2013; 6: 638-48.
Crossref Google Scholar
40

Mutschelknaus L, Peters C, Winkler K, Yentrapalli R, Heider T, Atkinson MJ, et al. Exosomes derived from squamous head and neck cancer promote cell survival after ionizing radiation. PLoS One. 2016; 11: e0152213.
Crossref Google Scholar
41

Lehmann BD, Paine MS, Brooks AM, Mccubrey JA, Renegar RH, Wang R, et al. Senescence-associated exosome release from human prostate cancer cells. Cancer Res. 2008; 68: 7864-71.
Crossref Google Scholar
42

Bagheri HS, Mousavi M, Rezabakhsh A, Rezaie J, Rasta SH, Nourazarian A, et al. Low-level laser irradiation at a high power intensity increased human endothelial cell exosome secretion via Wnt signaling. Lasers Med Sci. 2018; 33: 1131-45.
Crossref Google Scholar
43

Mallegol J, Van Niel G, Lebreton C, Lepelletier Y, Candalh C, Dugave C, et al. T84-intestinal epithelial exosomes bear MHC class Ⅱ/peptide complexes potentiating antigen presentation by dendritic cells. Gastroenterology. 2007; 132: 1866-76.
Crossref Google Scholar
44

Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015; 527: 329-35.
Crossref Google Scholar
45

Santonocito M, Vento M, Guglielmino MR, Battaglia R, Wahlgren J, Ragusa M, et al. Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation. Fertil Steril. 2014; 102: 1751-61.e1.
Crossref Google Scholar
46

Kibria G, Ramos EK, Wan Y, Gius DR, Liu H. Exosomes as a drug delivery system in cancer therapy: potential and challenges. Mol Pharm. 2018; 15: 3625-33.
Crossref Google Scholar
47

Armstrong JPK, Stevens MM. Strategic design of extracellular vesicle drug delivery systems. Adv Drug Deliv Rev. 2018; 130: 12-6.
Crossref Google Scholar
48

Zhu L, Oh JM, Gangadaran P, Kalimuthu S, Baek SH, Jeong SY, et al. Targeting and therapy of glioblastoma in a mouse model using exosomes derived from natural killer cells. Front Immunol. 2018; 9: 824.
Crossref Google Scholar
49

Hazawa M, Tomiyama K, Saotome-Nakamura A, Obara C, Yasuda T, Gotoh T, et al. Radiation increases the cellular uptake of exosomes through CD29/CD81 complex formation. Biochem Biophys Res Commun. 2014; 446: 1165-71.
Crossref Google Scholar
50

Jin X, Chen Y, Chen H, Fei S, Chen D, Cai X, et al. Evaluation of tumor-derived exosomal miRNA as potential diagnostic biomarkers for early-stage non-small cell lung cancer using nextgeneration sequencing. Clin Cancer Res. 2017; 23: 5311-9.
Crossref Google Scholar
51

Mitchell PJ, Welton J, Staffurth J, Court J, Mason MD, Tabi Z, et al. Can urinary exosomes act as treatment response markers in prostate cancer? J Transl Med. 2009; 7: 4.
Crossref Google Scholar
52

Tan SK, Pastori C, Penas C, Komotar RJ, Ivan ME, Wahlestedt C, et al. Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme. Mol Cancer. 2018; 17: 74.
Crossref Google Scholar
53

Zhang C, Yang X, Qi Q, Gao Y, Wei Q, Han S. lncRNA-HEIH in serum and exosomes as a potential biomarker in the HCV-related hepatocellular carcinoma. Cancer Biomark. 2018; 21: 651-9.
Crossref Google Scholar
54

Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Epigenomics. 2018; 10: 187-97.
Crossref Google Scholar
55

Nedaeinia R, Manian M, Jazayeri MH, Ranjbar M, Salehi R, Sharifi M, et al. Circulating exosomes and exosomal microRNAs as biomarkers in gastrointestinal cancer. Cancer Gene Ther. 2017; 24: 48-56.
Crossref Google Scholar
56

Bjornetro T, Handeland KR, Meltzer S, Samiappan R, Lyckander LG, Jegerschold C, et al. Abstract 4514: Low release of exosomal miR-663a from hypoxic tumor cells and poor tumor response to neoadjuvant radiotherapy in rectal cancer patients. Cancer Res. 2017; 77: 4514.
Crossref Google Scholar
57

An M, Lohse I, Tan Z, Zhu J, Wu J, Kurapati H, et al. Quantitative proteomic analysis of serum exosomes from patients with locally advanced pancreatic cancer undergoing chemoradiotherapy. J Proteome Res. 2017; 16: 1763-72.
Crossref Google Scholar
58

Kulkarni S, Koller A, Mani KM, Wen R, Alfieri A, Saha S, et al. Identifying urinary and serum exosome biomarkers for radiation exposure using a data dependent acquisition and SWATH-MS combined workflow. Int J Radiat Oncol Biol Phys. 2016; 96: 566-77.
Crossref Google Scholar
59

Malla B, Aebersold D M, Dal Pra A. Protocol for serum exosomal miRNAs analysis in prostate cancer patients treated with radiotherapy. J Transl Med. 2018; 16: 223.
Crossref Google Scholar
60

Yu Q, Li P, Weng M, Wu S, Zhang Y, Chen X, et al. Nano-vesicles are a potential tool to monitor therapeutic efficacy of carbon ion radiotherapy in prostate cancer. J Biomed Nanotechnol. 2018; 14: 168-78.
Crossref Google Scholar
61

Liao K, Ma X, Chen B, Lu X, Hu Y, Lin Y, et al. Upregulated AHIFmediated radioresistance in glioblastoma. Biochem Biophys Res Commun. 2019; 509: 617-23.
Crossref Google Scholar
62

Mo LJ, Song M, Huang QH, Guan H, Liu XD, Xie DF, et al. Exosome-packaged miR-1246 contributes to bystander DNA damage by targeting LIG4. Br J Cancer. 2018; 119: 492-502.
Crossref Google Scholar
63

Bao L, You B, Shi S, Shan Y, Zhang Q, Yue H, et al. Metastasisassociated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10. Oncogene. 2018; 37: 2873-89.
Crossref Google Scholar
64

Zheng Y, Liu L, Chen C, Ming P, Huang Q, Li C, et al. The extracellular vesicles secreted by lung cancer cells in radiation therapy promote endothelial cell angiogenesis by transferring miR-23a. Peer J. 2017; 5: e3627.
Crossref Google Scholar
65

Jiang H, Li Z, Li X, Xia J. Intercellular transfer of messenger RNAs in multiorgan tumorigenesis by tumor cell-derived exosomes. Mol Med Rep. 2015; 11: 4657-63.
Crossref Google Scholar
66

Harris DA, Patel SH, Gucek M, Hendrix A, Westbroek W, Taraska JW. Exosomes released from breast cancer carcinomas stimulate cell movement. PLoS One. 2015; 10: e0117495.
Crossref Google Scholar
67

Yentrapalli R, Merl-Pham J, Azimzadeh O, Mutschelknaus L, Peters C, Hauck SM, et al. Quantitative changes in the protein and miRNA cargo of plasma exosome-like vesicles after exposure to ionizing radiation. Int J Radiat Biol. 2017; 93: 569-80.
Crossref Google Scholar
68

Jelonek K, Wojakowska A, Marczak L, Muer A, Tinhofer-Keilholz I, Lysek-Gladysinska M, et al. Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma. Acta Biochim Pol. 2015; 62: 265-72.
Crossref Google Scholar
69

Abramowicz A, Wojakowska A, Marczak L, Lysek-Gladysinska M, Smolarz M, Story M D, et al. Ionizing radiation affects the composition of the proteome of extracellular vesicles released by head-and-neck cancer cells in vitro. J Radiat Res. 2019; 60: 289-97.
Crossref Google Scholar
70

Mutschelknaus L, Azimzadeh O, Heider T, Winkler K, Vetter M, Kell R, et al. Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells. Sci Rep. 2017; 7: 12423.
Crossref Google Scholar
71

Orzan F, De Bacco F, Crisafulli G, Pellegatta S, Mussolin B, Siravegna G, et al. Genetic evolution of glioblastoma stem-like cells from primary to recurrent tumor. Stem cells (Dayton, Ohio). 2017; 35: 2218-28.
Crossref Google Scholar
72

Abou-El-Ardat K, Seifert M, Becker K, Eisenreich S, Lehmann M, Hackmann K, et al. Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas. Neuro Oncol. 2017; 19: 546-57.
Crossref Google Scholar
73

Dai X, Liao K, Zhuang Z, Chen B, Zhou Z, Zhou S, et al. AHIF promotes glioblastoma progression and radioresistance via exosomes. Int J Oncol. 2019; 54: 261-70.
Crossref Google Scholar
74

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018; 68: 7-30.
Crossref Google Scholar
75

Dinh TK, Fendler W, Chalubinska-Fendler J, Acharya SS, O’leary C, Deraska PV, et al. Circulating miR-29a and miR-150 correlate with delivered dose during thoracic radiation therapy for non-small cell lung cancer. Radiat Oncol. 2016; 11: 61.
Crossref Google Scholar
76

Wu H, Zeng C, Ye Y, Liu J, Mu Z, Xie Y, et al. Exosomes from irradiated nonsmall cell lung cancer cells reduced sensitivity of recipient cells to anaplastic lymphoma kinase inhibitors. Mol Pharm. 2018; 15: 1892-900.
Crossref Google Scholar
77

Lundholm M, Schroder M, Nagaeva O, Baranov V, Widmark A, Mincheva-Nilsson L, et al. Prostate tumor-derived exosomes downregulate NKG2D expression on natural killer cells and CD8+ T cells: mechanism of immune evasion. PLoS One. 2014; 9: e108925.
Crossref Google Scholar
78

Al-Mayah AH, Irons SL, Pink RC, Carter DR, Kadhim MA. Possible role of exosomes containing RNA in mediating nontargeted effect of ionizing radiation. Radiat Res. 2012; 177: 539-45.
Crossref Google Scholar
79

Al-Mayah AH, Bright SJ, Bowler DA, Slijepcevic P, Goodwin E, Kadhim MA. Exosome-mediated telomere instability in human breast epithelial cancer cells after X irradiation. Radiat Res. 2017; 187: 98-106.
Crossref Google Scholar
80

Le M, Fernandez-Palomo C, Mcneill FE, Seymour CB, Rainbow AJ, Mothersill CE. Exosomes are released by bystander cells exposed to radiation-induced biophoton signals: reconciling the mechanisms mediating the bystander effect. PLoS One. 2017; 12: e0173685.
Crossref Google Scholar
81

Diamond JM, Vanpouille-Box C, Spada S, Rudqvist NP, Chapman JR, Ueberheide BM, et al. Exosomes shuttle TREX1-sensitive IFNstimulatory dsDNA from irradiated cancer cells to DCs. Cancer Immunol Res. 2018; 6: 910-20.
Crossref Google Scholar
82

Hurwitz MD, Kaur P, Nagaraja GM, Bausero MA, Manola J, Asea A. Radiation therapy induces circulating serum Hsp72 in patients with prostate cancer. Radiother Oncol. 2010; 95: 350-8.
Crossref Google Scholar
83

Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000; 407: 249-57.
Crossref Google Scholar
84

Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971; 285: 1182-6.
Crossref Google Scholar
85

Chiba M, Kubota S, Sato K, Monzen S. Exosomes released from pancreatic cancer cells enhance angiogenic activities via dynamindependent endocytosis in endothelial cells in vitro. Sci Rep. 2018; 8: 11972.
Crossref Google Scholar
86

Holzner S, Senfter D, Stadler S, Staribacher A, Nguyen CH, Gaggl A, et al. Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro. Oncol Rep. 2016; 36: 3065-71.
Crossref Google Scholar
87

Li G, Lin H, Tian R, Zhao P, Huang Y, Pang X, et al. VEGFR-2 inhibitor apatinib hinders endothelial cells progression triggered by irradiated gastric cancer cells-derived exosomes. J Cancer. 2018; 9: 4049-57.
Crossref Google Scholar
88

Jella KK, Rani S, O’driscoll L, Mcclean B, Byrne HJ, Lyng FM. Exosomes are involved in mediating radiation induced bystander signaling in human keratinocyte cells. Radiat Res. 2014; 181: 138-45.
Crossref Google Scholar
89

Xu S, Wang J, Ding N, Hu W, Zhang X, Wang B, et al. Exosomemediated microRNA transfer plays a role in radiation-induced bystander effect. RNA Biol. 2015; 12: 1355-63.
Crossref Google Scholar
90

De Araujo Farias V, O’valle F, Serrano-Saenz S, Anderson P, Andres E, Lopez-Penalver J, et al. Exosomes derived from mesenchymal stem cells enhance radiotherapy-induced cell death in tumor and metastatic tumor foci. Mol Cancer. 2018; 17: 122.
Crossref Google Scholar
91

Xu S, Liu C, Ji HL. Concise review: therapeutic potential of the mesenchymal stem cell derived secretome and extracellular vesicles for radiation-induced lung injury: progress and hypotheses. Stem Cells Transl Med. 2019; 8: 344-54.
Crossref Google Scholar
92

Wen S, Dooner M, Cheng Y, Papa E, Del Tatto M, Pereira M, et al. Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells. Leukemia. 2016; 30: 2221-31.
Crossref Google Scholar
93

Zuo R, Liu M, Wang Y, Li J, Wang W, Wu J, et al. BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/beta-catenin signaling. Stem Cell Res Ther. 2019; 10: 30.
Crossref Google Scholar
94

Zhang Y, Shi S, Xu Q, Zhang Q, Shanti RM, Le AD. SIS-ECM laden with GMSC-derived exosomes promote taste bud regeneration. J Dent Res. 2019; 98: 225-33.
Crossref Google Scholar
95

Zitvogel L, Regnault A, Lozier A, Wolfers J, Flament C, Tenza D, et al. Eradication of established murine tumors using a novel cellfree vaccine: dendritic cell-derived exosomes. Nat Med. 1998; 4: 594-600.
Crossref Google Scholar
96

Bowers JS, Nelson MH, Kundimi S, Bailey SR, Huff LW, Schwartz KM, et al. Dendritic cells in irradiated mice trigger the functional plasticity and antitumor activity of adoptively transferred Tc17 cells via IL12 signaling. Clin Cancer Res. 2015; 21: 2546-57.
Crossref Google Scholar
97

Schnitzer JK, Berzel S, Fajardo-Moser M, Remer KA, Moll H. Fragments of antigen-loaded dendritic cells (DC) and DC-derived exosomes induce protective immunity against Leishmania major. Vaccine. 2010; 28: 5785-93.
Crossref Google Scholar
98

Min H, Sun X, Yang X, Zhu H, Liu J, Wang Y, et al. Exosomes derived from irradiated esophageal carcinoma-infiltrating T cells promote metastasis by inducing the epithelial-mesenchymal transition in esophageal cancer cells. Pathol Oncol Res. 2018; 24: 11-8.
Crossref Google Scholar
99

Gunaydin G, Kesikli S A, Guc D. Cancer associated fibroblasts have phenotypic and functional characteristics similar to the fibrocytes that represent a novel MDSC subset. Oncoimmunology. 2015; 4: e1034918.
Crossref Google Scholar
100

Boelens MC, Wu TJ, Nabet BY, Xu B, Qiu Y, Yoon T, et al. Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. Cell. 2014; 159: 499-513.
Crossref Google Scholar
101

Ventimiglia LN, Alonso MA. Biogenesis and function of T Cellderived exosomes. Front Cell Develop Biol. 2016; 4: 84.
Crossref Google Scholar
102

Pitt JM, André F, Amigorena S, Soria JC, Eggermont A, Kroemer G, et al. Dendritic cell-derived exosomes for cancer therapy. J Clin Invest. 2016; 126: 1224-32.
Crossref Google Scholar
103

Fais S. NK cell-released exosomes: natural nanobullets against tumors. Oncoimmunology. 2013; 2: e22337.
Crossref Google Scholar
Cancer Biology & Medicine
Volume 18 Issue 1,
February 2021
Pages 21-33
DOI: 10.20892/j.issn.2095-3941.2020.0150
Cite this article:
He C, Li L, Wang L, et al. Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation. Cancer Biology & Medicine, 2021, 18(1): 21-33. https://doi.org/10.20892/j.issn.2095-3941.2020.0150

71

Views

2

Downloads

25

Crossref

26

Web of Science

27

Scopus

Altmetrics
Received: 23 April 2020
Accepted: 09 September 2020
Published: 01 February 2021
©2021 Cancer Biology & Medicine.

Creative Commons Attribution-NonCommercial 4.0 International License
Return