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Review | Open Access

Competing endogenous RNAs in lung cancer

Meilian Zhao1, Jianguo Feng2 ( ), Liling Tang1 ( )
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
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Abstract

Competing endogenous RNAs (ceRNAs) containing microRNA response elements can competitively interact with microRNA via miRNA response elements, which can combine non-coding RNAs with protein-coding RNAs through complex ceRNA networks. CeRNAs include non-coding RNAs (long non-coding RNAs, circular RNAs, and transcribed pseudogenes) and protein-coding RNAs (mRNAs). Molecular interactions in ceRNA networks can coordinate many biological processes; however, they may also lead to ceRNA network imbalance and thus contribute to cancer occurrence when disturbed. Recent studies indicate that many dysregulated RNAs derived from lung cancer may function as ceRNAs to regulate multitudinous biological functions for lung cancer, including tumor cell proliferation, apoptosis, growth, invasion, migration, and metastasis. This study therefore reviewed the research progress in the field of non-coding and protein-coding RNAs as ceRNAs in lung cancer, and highlighted validated ceRNAs involved in biological lung cancer functions. Furthermore, the roles of ceRNAs as novel prognostic and diagnostic biomarkers were also discussed. Interpreting the involvement of ceRNAs networks in lung cancer will provide new insight into cancer pathogenesis and treatment strategies.

Keywords

lung cancerbiomarkerCeRNAbiological functions

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Cancer Biology & Medicine
Volume 18 Issue 1,
February 2021
Pages 1-20
DOI: 10.20892/j.issn.2095-3941.2020.0203
Cite this article:
Zhao M, Feng J, Tang L. Competing endogenous RNAs in lung cancer. Cancer Biology & Medicine, 2021, 18(1): 1-20. https://doi.org/10.20892/j.issn.2095-3941.2020.0203

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Received: 02 May 2020
Accepted: 09 September 2020
Published: 01 February 2021
©2021 Cancer Biology & Medicine.

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