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Review | Open Access

Current research on circular RNAs and their potential clinical implications in breast cancer

Diya Liu, Lin Fang ( )
Department of Thyroid and Breast Diseases, Shanghai Tenth People’s Hospital, Shanghai 200070, China
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Abstract

Breast cancer (BC) is one of the most common cancers and the leading causes of death among women worldwide, and its morbidity rate is growing. Discovery of novel biomarkers is necessary for early BC detection, treatment, and prognostication. Circular RNAs (circRNAs), a novel type of endogenous non-coding RNAs with covalently closed continuous loops, have been found to have a crucial role in tumorigenesis. Studies have demonstrated that circRNAs are aberrantly expressed in the tumor tissues and plasma of patients with BC, and they modulate gene expression affecting the proliferation, metastasis, and chemoresistance of BC by specifically binding and regulating the expression of microRNAs (miRNAs). Therefore, circRNAs can be used as novel potential diagnostic and prognostic markers, and therapeutic targets for BC. This article summarizes the properties, functions, and regulatory mechanisms of circRNAs, particularly current research on their association with BC proliferation, metastasis, and chemoresistance.

Keywords

breast cancerbiomarkerCircular RNA

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Cancer Biology & Medicine
Volume 18 Issue 3,
August 2021
Pages 635-648
DOI: 10.20892/j.issn.2095-3941.2020.0275
Cite this article:
Liu D, Fang L. Current research on circular RNAs and their potential clinical implications in breast cancer. Cancer Biology & Medicine, 2021, 18(3): 635-648. https://doi.org/10.20892/j.issn.2095-3941.2020.0275

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Received: 03 June 2020
Accepted: 26 November 2020
Published: 01 August 2021
©2021 Cancer Biology & Medicine.

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