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Review | Open Access

Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies

Xueping Tao1,2, Yongfu Shao2 ( ), Jianing Yan1,2, Liyang Yang1,2, Qihua Ye1,2, Qingling Wang1,2, Rongdan Lu2, Junming Guo1,2 ( )
Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, China
Department of Gastroenterology, the Affiliated Hospital of Medical School of Ningbo University, Ningbo 315020, China
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Abstract

Circular RNAs (circRNAs), a class of endogenous RNA molecules, are produced by alternative splicing of precursor RNA and are covalently linked at the 5′ and 3′ ends. Recent studies have revealed that dysregulated circRNAs are closely related to the occurrence and progression of gastrointestinal malignancies. Accumulating evidence indicates that circRNAs, including circPVT1, circLARP4, circ-SFMBT2, cir-ITCH, circRNA_100782, circ_100395, circ-DONSON, hsa_circ_0001368, circNRIP1, circFAT1(e2), circCCDC66, circSMARCA5, circ-ZNF652, and circ_0030235 play important roles in the proliferation, differentiation, invasion, and metastasis of cancer cells through a variety of mechanisms, such as acting as microRNA sponges, interacting with RNA-binding proteins, regulating gene transcription and alternative splicing, and being translated into proteins. With the characteristics of high abundance, high stability, extensive functions, and certain tissue-, time- and disease-specific expressions, circRNAs are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies.

Keywords

digestive systemCircular RNAbiological functiongastrointestinal malignanciesclinical value

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Cancer Biology & Medicine
Volume 18 Issue 2,
May 2021
Pages 437-457
DOI: 10.20892/j.issn.2095-3941.2020.0348
Cite this article:
Tao X, Shao Y, Yan J, et al. Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies. Cancer Biology & Medicine, 2021, 18(2): 437-457. https://doi.org/10.20892/j.issn.2095-3941.2020.0348

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Received: 29 June 2020
Accepted: 19 November 2020
Published: 01 May 2021
©2021 Cancer Biology & Medicine.

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