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Review | Open Access

The biogenesis, function and clinical significance of circular RNAs in breast cancer

Yan Zeng, Yutian Zou, Guanfeng Gao, Shaoquan Zheng, Song Wu, Xiaoming Xie( ), Hailin Tang ( )
Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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Abstract

Circular RNAs (circRNAs) are noncoding RNAs that form covalently closed loop structures. CircRNAs are dysregulated in cancer and play key roles in tumorigenesis, diagnosis, and tumor therapy. CircRNAs function as competing endogenous RNAs or microRNA sponges that regulate transcription and splicing, binding to proteins, and translation. CircRNAs may serve as novel biomarkers for cancer diagnosis, and they show potential as therapeutic targets in cancers including breast cancer (BC). In women, BC is the most common malignant tumor worldwide and the second leading cause of cancer death. Although evidence indicates that circRNAs play a critical role in BC, the mechanisms regulating the function of circRNAs in BC remain poorly understood. Here, we provide literature review aiming to clarify the role of circRNAs in BC and summarize the latest research. We provide a systematic overview of the biogenesis and biological functions of circRNAs, elaborate on the functional roles of circRNAs in BC, and highlight the value of circRNAs as diagnostic and therapeutic targets in BC.

Keywords

Breast cancertargeted therapycircular RNAstumor biomarkercarcinogenesis

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Cancer Biology & Medicine
Volume 19 Issue 1,
January 2022
Pages 14-29
DOI: 10.20892/j.issn.2095-3941.2020.0485
Cite this article:
Zeng Y, Zou Y, Gao G, et al. The biogenesis, function and clinical significance of circular RNAs in breast cancer. Cancer Biology & Medicine, 2022, 19(1): 14-29. https://doi.org/10.20892/j.issn.2095-3941.2020.0485

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Received: 20 August 2020
Accepted: 13 January 2021
Published: 21 March 2022
©2022 Cancer Biology & Medicine.

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