AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Cancer Biology & Medicine Article
PDF (1.5 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Review | Open Access

Recent progress of nanotechnology-based theranostic systems in cancer treatments

Ying Xue1, Yuting Gao1, Fanling Meng1,2, Liang Luo1,2,3 ( )
National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
Research Institute of Huazhong University of Science and Technology in Shenzhen, Shenzhen 518057, China
Show Author Information

Abstract

Theranostics that integrates therapy and diagnosis in one system to achieve accurate cancer diagnosis and treatment has attracted tremendous interest, and has been recognized as a potential breakthrough in overcoming the challenges of conventional oncotherapy. Nanoparticles are ideal candidates as carriers for theranostic agents, which is attributed to their extraordinary physicochemical properties, including nanoscale sizes, functional properties, prolonged blood circulation, active or passive tumor targeting, specific cellular uptake, and in some cases, excellent optical properties that ideally meet the needs of phototherapy and imaging at the same time. Overall, with the development of nanotechnology, theranostics has become a reality, and is now in the transition stage of “bench to bedside.” In this review, we summarize recent progress on nanotechnology-based theranostics, i.e., nanotheranostics, that has greatly assisted traditional therapies, and has provided therapeutic strategies emerging in recent decades, as well as “cocktail” theranostics mixing various treatment modalities.

Keywords

nanoparticlesdiagnosisTheranosticsnanotechnologycancer therapy

References

1

Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Niksic M, et al. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018; 391: 1023-75.
Crossref Google Scholar
2

Lin G, Mi P, Chu C, Zhang J, Liu G. Inorganic nanocarriers overcoming multidrug resistance for cancer theranostics. Adv Sci. 2016; 3: 1600134.
Crossref Google Scholar
3

Yao VJ, D’Angelo S, Butler KS, Theron C, Smith TL, Marchio S, et al. Ligand-targeted theranostic nanomedicines against cancer. J Control Release. 2016; 240: 267-86.
Crossref Google Scholar
4

Semkina AS, Abakumov MA, Skorikov AS, Abakumova TO, Melnikov PA, Grinenko NF, et al. Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer. Nanomedicine. 2018; 14: 1733-42.
Crossref Google Scholar
5

Baetke S C, Lammers T, Kiessling F. Applications of nanoparticles for diagnosis and therapy of cancer. Br J Radiol. 2015; 88: 20150207.
Crossref Google Scholar
6

Feng G, Liu B. Multifunctional AIEgens for future theranostics. Small. 2016; 12: 6528-35.
Crossref Google Scholar
7

Li S, Zou Q, Xing R, Govindaraju T, Fakhrullin R, Yan X. Peptide-modulated self-assembly as a versatile strategy for tumor supramolecular nanotheranostics. Theranostics. 2019; 9: 3249-61.
Crossref Google Scholar
8

Kalyane D, Raval N, Maheshwari R, Tambe V, Kalia K, Tekade RK. Employment of enhanced permeability and retention effect (EPR): nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer. Mater Sci Eng C Mater Biol Appl. 2019; 98: 1252-76.
Crossref Google Scholar
9

Guo X, Wei X, Chen Z, Zhang XB, Yang G, Zhou SB. Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy. Prog Mater Sci. 2020; 107: 24.
Crossref Google Scholar
10

Andreou C, Pal S, Rotter L, Yang J, Kircher MF. Molecular imaging in nanotechnology and theranostics. Mol Imaging Biol. 2017; 19: 363-72.
Crossref Google Scholar
11

Xie J, Lee S, Chen X. Nanoparticle-based theranostic agents. Adv Drug Deliv Rev. 2010; 62: 1064-79.
Crossref Google Scholar
12

Jo SD, Ku SH, Won Y-Y, Kim SH, Kwon IC. Targeted nanotheranostics for future personalized medicine: recent progress in cancer therapy. Theranostics. 2016; 6: 1362-77.
Crossref Google Scholar
13

Mi Y, Shao Z, Vang J, Kaidar-Person O, Wang AZ. Application of nanotechnology to cancer radiotherapy. Cancer Nanotechnol. 2016; 7: 11.
Crossref Google Scholar
14

Chen H, Zhang W, Zhu G, Xie J, Chen X. Rethinking cancer nanotheranostics. Nat Rev Mater. 2017; 2: 17024.
Crossref Google Scholar
15

Zhao CY, Cheng R, Yang Z, Tian ZM. Nanotechnology for cancer therapy based on chemotherapy. Molecules. 2018; 23: 826.
Crossref Google Scholar
16

Xing H, Hwang K, Lu Y. Recent developments of liposomes as nanocarriers for theranostic applications. Theranostics. 2016; 6: 1336-52.
Crossref Google Scholar
17

Choi KY, Han HS, Lee ES, Shin JM, Almquist BD, Lee DS, et al. Hyaluronic acid-based activatable nanomaterials for stimuli-responsive imaging and therapeutics: beyond CD44-mediated drug delivery. Adv Mater. 2019; 31: 1803549.
Crossref Google Scholar
18

Luo M, Fan T, Zhou Y, Zhang H, Mei L. 2d black phosphorus–based biomedical applications. Adv Funct Mater. 2019; 29: 1808306.
Crossref Google Scholar
19

Li Z, Barnes JC, Bosoy A, Stoddart JF, Zink JI. Mesoporous silica nanoparticles in biomedical applications. Chem Soc Rev. 2012; 41: 2590-605.
Crossref Google Scholar
20

Fan M, Han Y, Gao S, Yan H, Cao L, Li Z, et al. Ultrasmall gold nanoparticles in cancer diagnosis and therapy. Theranostics. 2020; 10: 4944-57.
Crossref Google Scholar
21

Chen XJ, Zhang XQ, Liu Q, Zhang J, Zhou G. Nanotechnology: a promising method for oral cancer detection and diagnosis. J Nanobiotechnol. 2018; 16: 52.
Crossref Google Scholar
22

Haume K, Rosa S, Grellet S, Smialek MA, Butterworth KT, Solov’yov AV, et al. Gold nanoparticles for cancer radiotherapy: a review. Cancer Nanotechnol. 2016; 7: 8.
Crossref Google Scholar
23

Liu YJ, Bhattarai P, Dai ZF, Chen XY. Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev. 2019; 48: 2053-108.
Crossref Google Scholar
24

Al-Jamal WT, Kostarelos K. Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine. Acc Chem Res. 2011; 44: 1094-104.
Crossref Google Scholar
25

Li J, Hu Y, Yang J, Wei P, Sun W, Shen M, et al. Hyaluronic acid-modified Fe3O4@Au core/shell nanostars for multimodal imaging and photothermal therapy of tumors. Biomaterials. 2015; 38: 10-21.
Crossref Google Scholar
26

Zhang L, Gao S, Zhang F, Yang K, Ma Q, Zhu L. Activatable hyaluronic acid nanoparticle as a theranostic agent for optical/photoacoustic image-guided photothermal therapy. ACS Nano. 2014; 8: 12250-8.
Crossref Google Scholar
27

Kaaki K, Herve-Aubert K, Chiper M, Shkilnyy A, Souce M, Benoit R, et al. Magnetic nanocarriers of doxorubicin coated with poly(ethylene glycol) and folic acid: relation between coating structure, surface properties, colloidal stability, and cancer cell targeting. Langmuir. 2012; 28: 1496-505.
Crossref Google Scholar
28

Liu X, Wang C, Liu Z. Protein-engineered biomaterials for cancer theranostics. Adv Healthc Mater. 2018; 7: 1800913.
Crossref Google Scholar
29

Yan Y, Dong Y, Yue S, Qiu X, Sun H, Zhong Z. Dually active targeting nanomedicines based on a direct conjugate of two purely natural ligands for potent chemotherapy of ovarian tumors. ACS Appl Mater Interfaces. 2019; 11: 46548-57.
Crossref Google Scholar
30

Cherkasov VR, Mochalova EN, Babenyshev AV, Rozenberg JM, Sokolov IL, Nikitin MP. Antibody-directed metal-organic framework nanoparticles for targeted drug delivery. Acta Biomater. 2020; 103: 223-36.
Crossref Google Scholar
31

Swierczewska M, Han HS, Kim K, Park JH, Lee S. Polysaccharide-based nanoparticles for theranostic nanomedicine. Adv Drug Deliv Rev. 2016; 99: 70-84.
Crossref Google Scholar
32

Hou WX, Zhao X, Qian XQ, Pan F, Zhang CL, Yang YM, et al. Ph-sensitive self-assembling nanoparticles for tumor near-infrared fluorescence imaging and chemo-photodynamic combination therapy. Nanoscale. 2016; 8: 104-16.
Crossref Google Scholar
33

Horcajada P, Chalati T, Serre C, Gillet B, Sebrie C, Baati T, et al. Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. Nat Mater. 2010; 9: 172-8.
Crossref Google Scholar
34

Tao W, Zhu X, Yu X, Zeng X, Xiao Q, Zhang X, et al. Black phosphorus nanosheets as a robust delivery platform for cancer theranostics. Adv Mater. 2017; 29: 1603276.
Crossref Google Scholar
35

Herrmann K, Schwaiger M, Lewis JS, Solomon SB, McNeil BJ, Baumann M, et al. Radiotheranostics: a roadmap for future development. Lancet Oncol. 2020; 21: e146-56.
Crossref Google Scholar
36

Ma G, Liu X, Deng G, Yuan H, Wang Q, Lu J. A novel theranostic agent based on porous bismuth nanosphere for CT imaging-guided combined chemo-photothermal therapy and radiotherapy. J Mater Chem B. 2018; 6: 6788-95.
Crossref Google Scholar
37

Fani M, Peitl PK, Velikyan I. Current status of radiopharmaceuticals for the theranostics of neuroendocrine neoplasms. Pharmaceuticals. 2017; 10: 30.
Crossref Google Scholar
38

Jadvar H, Chen X, Cai W, Mahmood U. Radiotheranostics in cancer diagnosis and management. Radiology. 2018; 286: 388-400.
Crossref Google Scholar
39

Song Z, Chang Y, Xie H, Yu X-F, Chu PK, Chen T. Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy. Npg Asia Mater. 2017; 9: e439.
Crossref Google Scholar
40

Iikuni S, Ono M, Watanabe H, Shimizu Y, Sano K, Saji H. Cancer radiotheranostics targeting carbonic anhydrase-IX with in-111- and y-90-labeled ureidosulfonamide scaffold for SPECT imaging and radionuclide-based therapy. Theranostics. 2018; 8: 2992-3006.
Crossref Google Scholar
41

Mishiro K, Hanaoka H, Yamaguchi A, Ogawa K. Radiotheranostics with radiolanthanides: design, development strategies, and medical applications. Coord Chem Rev. 2019; 383: 104-31.
Crossref Google Scholar
42

Du J, Gu Z, Yan L, Yong Y, Yi X, Zhang X, et al. Poly(vinylpyrollidone)- and selenocysteine-modified Bi2Se3 nanoparticles enhance radiotherapy efficacy in tumors and promote radioprotection in normal tissues. Adv Mater. 2017; 29: 1701268.
Crossref Google Scholar
43

Gao K, Tu W, Yu X, Ahmad F, Zhang X, Wu W, et al. W-doped TiO2 nanoparticles with strong absorption in the NIR-II window for photoacoustic/CT dual-modal imaging and synergistic thermoradiotherapy of tumors. Theranostics. 2019; 9: 5214-26.
Crossref Google Scholar
44

Wang Q, Xia B, Xu J, Niu X, Cai J, Shen Q, et al. Biocompatible small organic molecule phototheranostics for NIR-II fluorescence/photoacoustic imaging and simultaneous photodynamic/photothermal combination therapy. Mater Chem Front. 2019; 3: 650-5.
Crossref Google Scholar
45

Yi G, Hong SH, Son J, Yoo J, Park C, Choi Y, et al. Recent advances in nanoparticle carriers for photodynamic therapy. Quant Imaging Med Surg. 2018; 8: 433-43.
Crossref Google Scholar
46

Yu J, Rong Y, Kuo C-T, Zhou X-H, Chiu DT. Recent advances in the development of highly luminescent semiconducting polymer dots and nanoparticles for biological imaging and medicine. Anal Chem. 2017; 89: 42-56.
Crossref Google Scholar
47

Zhou J, Zhang Y, Yu G, Crawley MR, Fulong CRP, Friedman AE, et al. Highly emissive self-assembled BODIPY-platinum supramolecular triangles. J Am Chem Soc. 2018; 140: 7730-36.
Crossref Google Scholar
48

Li J, Zhen X, Lyu Y, Jiang Y, Huang J, Pu K. Cell membrane coated semiconducting polymer nanoparticles for enhanced multimodal cancer phototheranostics. ACS Nano. 2018; 12: 8520-30.
Crossref Google Scholar
49

Yu Z, Zhou P, Pan W, Li N, Tang B. A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis. Nat Commun. 2018; 9: 5044.
Crossref Google Scholar
50

Yuan Y, Kwok RTK, Tang BZ, Liu B. Targeted theranostic platinum(IV) prodrug with a built-in aggregation-induced emission light-up apoptosis sensor for noninvasive early evaluation of its therapeutic responses in situ. J Am Chem Soc. 2014; 136: 2546-54.
Crossref Google Scholar
51

Yuan Y, Zhang C-J, Gao M, Zhang R, Tang BZ, Liu B. Specific light-up bioprobe with aggregation-induced emission and activatable photoactivity for the targeted and image-guided photodynamic ablation of cancer cells. Angew Chem Int Ed. 2015; 54: 1780-6.
Crossref Google Scholar
52

Shi H, Kwok RTK, Liu J, Xing B, Tang BZ, Liu B. Real-time monitoring of cell apoptosis and drug screening using fluorescent light-up probe with aggregation-induced emission characteristics. J Am Chem Soc. 2012; 134: 17972-81.
Crossref Google Scholar
53

Mei J, Leung NLC, Kwok RTK, Lam JWY, Tang BZ. Aggregation-induced emission: together we shine, united we soar! Chem Rev. 2015; 115: 11718-940.
Crossref Google Scholar
54

Gao YT, Wang XX, He XW, He ZY, Yang X, Tian SD, et al. A dual-functional photosensitizer for ultraefficient photodynamic therapy and synchronous anticancer efficacy monitoring. Adv Funct Mater. 2019; 29: 1902673.
Crossref Google Scholar
55

Wang X, Tong J, He Z, Yang X, Meng F, Liang H, et al. Paclitaxel-potentiated photodynamic theranostics for synergistic tumor ablation and precise anticancer efficacy monitoring. ACS Appl Mater Interfaces. 2020; 12: 5476-87.
Crossref Google Scholar
56

Gao Y, He Z, He X, Zhang H, Weng J, Yang X, et al. Dual-color emissive AIEgen for specific and label-free double-stranded dna recognition and single-nucleotide polymorphisms detection. J Am Chem Soc. 2019; 141: 20097-106.
Crossref Google Scholar
57

Wu M, Wu L, Li J, Zhang D, Lan S, Zhang X, et al. Self-luminescing theranostic nanoreactors with intraparticle relayed energy transfer for tumor microenvironment activated imaging and photodynamic therapy. Theranostics. 2019; 9: 20-33.
Crossref Google Scholar
58

Avci P, Karimi M, Sadasivam M, Antunes-Melo WC, Carrasco E, Hamblin MR. In-vivo monitoring of infectious diseases in living animals using bioluminescence imaging. Virulence. 2018; 9: 28-63.
Crossref Google Scholar
59

Yang Y, Hou W, Liu S, Sun K, Li M, Wu C. Biodegradable polymer nanoparticles for photodynamic therapy by bioluminescence resonance energy transfer. Biomacromolecules. 2018; 19: 201-8.
Crossref Google Scholar
60

Karimi M, Zangabad PS, Baghaee-Ravari S, Ghazadeh M, Mirshekari H, Hamblin MR. Smart nanostructures for cargo delivery: uncaging and activating by light. J Am Chem Soc. 2017; 139: 4584-610.
Crossref Google Scholar
61

Kim M, Lee J-H, Nam J-M. Plasmonic photothermal nanoparticles for biomedical applications. Adv Sci. 2019; 6: 1900471.
Crossref Google Scholar
62

Wang H, Li X, Tse BW-C, Yang H, Thorling CA, Liu Y, et al. Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics. 2018; 8: 1227-42.
Crossref Google Scholar
63

An F-F, Zhang X-H. Strategies for preparing albumin-based nanoparticles for multifunctional bioimaging and drug delivery. Theranostics. 2017; 7: 3667-89.
Crossref Google Scholar
64

Chen Q, Liang C, Sun X, Chen J, Yang Z, Zhao H, et al. H2O2-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay. Proc Natl Acad Sci USA. 2017; 114: 5343-8.
Crossref Google Scholar
65

Zhou L, Jing Y, Liu Y, Liu Z, Gao D, Chen H, et al. Mesoporous carbon nanospheres as a multifunctional carrier for cancer theranostics. Theranostics. 2018; 8: 663-75.
Crossref Google Scholar
66

Cao Z, Feng L, Zhang G, Wang J, Shen S, Li D, et al. Semiconducting polymer-based nanoparticles with strong absorbance in NIR-II window for in vivo photothermal therapy and photoacoustic imaging. Biomaterials. 2018; 155: 103-11.
Crossref Google Scholar
67

Wang J, Yao C, Shen B, Zhu X, Li Y, Shi L, et al. Upconversion-magnetic carbon sphere for near infrared light-triggered bioimaging and photothermal therapy. Theranostics. 2019; 9: 608-19.
Crossref Google Scholar
68

Chen W, Ouyang J, Liu H, Chen M, Zeng K, Sheng J, et al. Black phosphorus nanosheet-based drug delivery system for synergistic photodynamic/photothermal/chemotherapy of cancer. Adv Mater. 2017; 29: 1603864.
Crossref Google Scholar
69

Dong Z, Gong H, Gao M, Zhu W, Sun X, Feng L, et al. Polydopamine nanoparticles as a versatile molecular loading platform to enable imaging-guided cancer combination therapy. Theranostics. 2016; 6: 1031-42.
Crossref Google Scholar
70

Yin F, Hu K, Chen Y, Yu M, Wang D, Wang Q, et al. SiRNA delivery with pegylated graphene oxide nanosheets for combined photothermal and genetherapy for pancreatic cancer. Theranostics. 2017; 7: 1133-48.
Crossref Google Scholar
71

Yu A-M, Jian C, Yu A H, Tu M-J. RNA therapy: are we using the right molecules? Pharmacol Ther. 2019; 196: 91-104.
Crossref Google Scholar
72

Wang J, Mi P, Lin G, Wang YXJ, Liu G, Chen X. Imaging-guided delivery of RNAi for anticancer treatment. Adv Drug Del Rev. 2016; 104: 44-60.
Crossref Google Scholar
73

Zheng X, Zhang F, Zhao Y, Zhang J, Dawulieti J, Pan Y, et al. Self-assembled dual fluorescence nanoparticles for CD44-targeted delivery of anti-miR-27a in liver cancer theranostics. Theranostics. 2018; 8: 3808-23.
Crossref Google Scholar
74

Kim MW, Jeong HY, Kang SJ, Jeong IH, Choi MJ, You YM, et al. Anti-EGF receptor aptamer-guided co-delivery of anti-cancer siRNAs and quantum dots for theranostics of triple-negative breast cancer. Theranostics. 2019; 9: 837-52.
Crossref Google Scholar
75

Ammari M, Presumey J, Ponsolles C, Roussignol G, Roubert C, Escriou V, et al. Delivery of miR-146a to Ly6C(high) monocytes inhibits pathogenic bone erosion in inflammatory arthritis. Theranostics. 2018; 8: 5972-85.
Crossref Google Scholar
76

Bertoli G, Cava C, Castiglioni I. MicroRNAs as biomarkers for diagnosis, prognosis and theranostics in prostate cancer. Int J Mol Sci. 2016; 17: 421.
Crossref Google Scholar
77

Hwang DW, Kim HY, Li F, Park JY, Kim D, Park JH, et al. In vivo visualization of endogenous miR-21 using hyaluronic acid-coated graphene oxide for targeted cancer therapy. Biomaterials. 2017; 121: 144-54.
Crossref Google Scholar
78

Petrescu GED, Sabo AA, Torsin LI, Calin GA, Dragomir MP. MicroRNA based theranostics for brain cancer: basic principles. J Exp Clin Cancer Res. 2019; 38: 231.
Crossref Google Scholar
79

Guo W, Wang H, Yang Y, Guo S, Zhang W, Liu Y, et al. Down-regulated miR-23a contributes to the metastasis of cutaneous melanoma by promoting autophagy. Theranostics. 2017; 7: 2231-49.
Crossref Google Scholar
80

Yan N, Wang X, Lin L, Song T, Sun P, Tian H, et al. Gold nanorods electrostatically binding nucleic acid probe for in vivo microRNA amplified detection and photoacoustic imaging-guided photothermal therapy. Adv Funct Mater. 2018; 28: 1800490.
Crossref Google Scholar
81

Sun B, Li J, Shao D, Pan Y, Chen Y, Li S, et al. Adipose tissue-secreted miR-27a promotes liver cancer by targeting FOXO1 in obese individuals. Onco Targets Ther. 2015; 8: 735-44.
Crossref Google Scholar
82

Ni Q, Zhang F, Zhang Y, Zhu G, Wang Z, Teng Z, et al. In Situ shRNA synthesis on DNA-polylactide nanoparticles to treat multidrug resistant breast cancer. Adv Mater. 2018; 30: 1705737.
Crossref Google Scholar
83

Zhu G, Mei L, Vishwasrao HD, Jacobson O, Wang Z, Liu Y, et al. Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy. Nat Commun. 2017; 8: 1482.
Crossref Google Scholar
84

Jang B, Kwon H, Katila P, Lee SJ, Lee H. Dual delivery of biological therapeutics for multimodal and synergistic cancer therapies. Adv Drug Del Rev. 2016; 98: 113-33.
Crossref Google Scholar
85

Zhang L, Zhang M, Zhou L, Han Q, Chen X, Li S, et al. Dual drug delivery and sequential release by amphiphilic Janus nanoparticles for liver cancer theranostics. Biomaterials. 2018; 181: 113-25.
Crossref Google Scholar
86

Teo PY, Cheng W, Hedrick JL, Yang YY. Co-delivery of drugs and plasmid DNA for cancer therapy. Adv Drug Del Rev. 2016; 98: 41-63.
Crossref Google Scholar
87

Zhong X, Yang K, Dong Z, Yi X, Wang Y, Ge C, et al. Polydopamine as a biocompatible multifunctional nanocarrier for combined radioisotope therapy and chemotherapy of cancer. Adv Funct Mater. 2015; 25: 7327-36.
Crossref Google Scholar
88

Jaidev LR, Chellappan DR, Bhaysar DV, Ranganathan R, Sivanantham B, Subramanian A, et al. Multi-functional nanoparticles as theranostic agents for the treatment & imaging of pancreatic cancer. Acta Biomater. 2017; 49: 422-33.
Crossref Google Scholar
89

Chen W, Zeng K, Liu H, Ouyang J, Wang L, Liu Y, et al. Cell membrane camouflaged hollow prussian blue nanoparticles for synergistic photothermal-/chemotherapy of cancer. Adv Funct Mater. 2017; 27: 1605795.
Crossref Google Scholar
90

Min KH, Kim Y-H, Wang Z, Kim J, Kim JS, Kim SH, et al. Engineered Zn(Ⅱ)-dipicolylamine-gold nanorod provides effective prostate cancer treatment by combining siRNA delivery and photothermal therapy. Theranostics. 2017; 7: 4240-54.
Crossref Google Scholar
91

Liu Y, Zhen W, Jin L, Zhang S, Sun G, Zhang T, et al. All-in-one theranostic nanoagent with enhanced reactive oxygen species generation and modulating tumor microenvironment ability for effective tumor eradication. ACS Nano. 2018; 12: 4886-93.
Crossref Google Scholar
92

Zhang L, Su H, Wang H, Li Q, Li X, Zhou C, et al. Tumor chemo-radiotherapy with rod-shaped and spherical gold nano probes: shape and active targeting both matter. Theranostics. 2019; 9: 1893-908.
Crossref Google Scholar
93

Detappe A, Thomas E, Tibbitt MW, Kunjachan S, Zavidij O, Parnandi N, et al. Ultrasmall silica-based bismuth gadolinium nanoparticles for dual magnetic resonance-computed tomography image guided radiation therapy. Nano Lett. 2017; 17: 1733-40.
Crossref Google Scholar
94

Truffi M, Fiandra L, Sorrentino L, Monieri M, Corsi F, Mazzucchelli S. Ferritin nanocages: a biological platform for drug delivery, imaging and theranostics in cancer. Pharmacol Res. 2016; 107: 57-65.
Crossref Google Scholar
95

Chen Y, Wu Y, Sun B, Liu S, Liu H. Two-dimensional nanomaterials for cancer nanotheranostics. Small. 2017; 13: 1603446.
Crossref Google Scholar
Cancer Biology & Medicine
Volume 18 Issue 2,
May 2021
Pages 336-351
DOI: 10.20892/j.issn.2095-3941.2020.0510
Cite this article:
Xue Y, Gao Y, Meng F, et al. Recent progress of nanotechnology-based theranostic systems in cancer treatments. Cancer Biology & Medicine, 2021, 18(2): 336-351. https://doi.org/10.20892/j.issn.2095-3941.2020.0510

73

Views

0

Downloads

29

Crossref

22

Web of Science

26

Scopus

Altmetrics
Received: 30 August 2020
Accepted: 30 December 2020
Published: 01 May 2021
©2021 Cancer Biology & Medicine.

Creative Commons Attribution-NonCommercial 4.0 International License
Return