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Original Article | Open Access

Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a prospective follow-up study

Wenhui Wu1,*, Zongchao Liu1,*, Zhexuan Li1, Weidong Liu2, Lanfu Zhang3, Yang Zhang1, Tong Zhou1, Weicheng You1, Kaifeng Pan1 ( ), Wenqing Li1 ( )
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Haidian District, Beijing 100142, China
Linqu County Public Health Bureau, Linqu 262600, China
Linqu County People’s Hospital, Linqu 262600, China

*These authors contributed equally to this work.

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Abstract

Objective

This study aimed at examining the alterations in metabolomic profiles caused by treatment of H. pylori infection, and the associations between key plasma metabolites and the risk of gastric lesion progression during follow-up after treatment.

Methods

An intervention trial was performed in 183 participants, 117 of whom were H. pylori positive participants receiving treatment for H. pylori infection. H. pylori positive participants were prospectively followed for 182 to 1,289 days. Untargeted metabolomics assays were conducted on plasma samples collected at baseline, 6 months after treatment, and during continued follow-up.

Results

We identified 59 metabolites with differential posttreatment changes between participants with successful and failed H. pylori eradication, 17 metabolites significantly distinguished participants with successful vs. failed eradication. Two metabolites [PC(18:1(11Z)/14:1(9Z)) and (2S)-6-amino-2-formamidohexanamide] showed posttreatment changes positively associated with successful H. pylori eradication, and were inversely associated with the risk of gastric lesion progression among participants with successful eradication. In contrast, 9-decenoic acid showed posttreatment changes inversely associated with successful eradication: its level was positively associated with the risk of gastric lesion progression among participants with successful eradication. Although the identified metabolites showed a temporary but significant decline after treatment, the trend generally reversed during continued follow-up, and pretreatment levels were restored.

Conclusions

Treatment of H. pylori infection significantly altered plasma metabolic profiles in the short term, and key metabolites were capable of distinguishing participants with successful vs. failed eradication, but might not substantially affect metabolic regulation in the long term. Several plasma metabolites were differentially associated with the risk of gastric lesion progression among participants with successful or failed eradication.

Keywords

metabolomicsgastric cancerHelicobacter pylori infectiongastric lesioneradication

Electronic Supplementary Material

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Cancer Biology & Medicine
Volume 19 Issue 8,
August 2022
Pages 1259-1273
DOI: 10.20892/j.issn.2095-3941.2022.0255
Cite this article:
Wu W, Liu Z, Li Z, et al. Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a prospective follow-up study. Cancer Biology & Medicine, 2022, 19(8): 1259-1273. https://doi.org/10.20892/j.issn.2095-3941.2022.0255

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Received: 07 May 2022
Accepted: 17 June 2022
Published: 29 August 2022
©2022 Cancer Biology & Medicine.

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