Home Cancer Biology & Medicine Article
PDF (563.7 KB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript
Perspective | Open Access

Recent research hotspots in sequencing and the pancreatic neuroendocrine tumor microenvironment

Junfeng Xu1,2,3,4,5,*, Wuhu Zhang1,2,3,4,5,*, Xin Lou1,2,3,4,5, Zeng Ye1,2,3,4,5, Yi Qin1,2,3,4,5, Jie Chen2,3, Xiaowu Xu1,2,3,4,5, Xianjun Yu1,2,3,4,5 (), Shunrong Ji1,2,3,4,5 ()
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Center for Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Shanghai Pancreatic Cancer Institute, Shanghai 200032, China
Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China

*The authors contributed equally to this work.

Show Author Information

References

1

Xu J, Ye Z, Zhuo Q, Gao H, Qin Y, Lou X, et al. MEN1 degradation induced by neddylation and the CUL4B-DCAF7 axis promotes pancreatic neuroendocrine tumor progression. Cancer Res. 2023; 83: 2226-47.

Crossref Google Scholar
2

Li H, Liu H, Chen K. Living biobank-based cancer organoids: prospects and challenges in cancer research. Cancer Biol Med. 2022; 19: 965-82.

Crossref Google Scholar
3

Zhang WH, Xu JF, Hu YH, Qin Y, Chen J, Yu XJ, et al. The surgical and therapeutic activities of non-functional pancreatic neuroendocrine tumors at a high-volume institution. Cancers (Basel). 2023; 15: 1955.

Crossref Google Scholar
4

Jiang R, Hong X, Zhao Y, Wu W. Application of multiomics sequencing and advances in the molecular mechanisms of pancreatic neuroendocrine neoplasms. Cancer Lett. 2021; 499: 39-48.

Crossref Google Scholar
5

Ji SR, Xu XW, Yu XJ. Advances in basic and translational research in neuroendocrine neoplasms. Zhonghua Wei Chang Wai Ke Za Zhi. 2021; 24: 867-74.

Google Scholar
6

Bai R, Li W, Cui J. Potential new applications of immunotherapy for neuroendocrine neoplasms: immune landscape, current status and future perspectives. Cancer Biol Med. 2022; 19: 1649-61.

Crossref Google Scholar
7

Cao Y, Gao Z, Li L, Jiang X, Shan A, Cai J, et al. Whole exome sequencing of insulinoma reveals recurrent T372R mutations in YY1. Nat Commun. 2013; 4: 2810.

Crossref Google Scholar
8

Keutgen XM, Kumar S, Gara SK, Boufraqech M, Agarwal S, Hruban RH, et al. Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype. Cancer. 2018; 124: 636-47.

Crossref Google Scholar
9

Xiao Y, Yu TJ, Xu Y, Ding R, Wang YP, Jiang YZ, et al. Emerging therapies in cancer metabolism. Cell Metab. 2023; 35: 1283-303.

Crossref Google Scholar
10

Ma Y, Zhu Q, Wang X, Liu M, Chen Q, Jiang L, et al. Synthetic lethal screening identifies DHODH as a target for MEN1-mutated tumor cells. Cell Res. 2022; 32: 596-9.

Crossref Google Scholar
11

Ye Z, Chen H, Ji S, Hu Y, Lou X, Zhang W, et al. MEN1 promotes ferroptosis by inhibiting mTOR-SCD1 axis in pancreatic neuroendocrine tumors. Acta Biochim Biophys Sin (Shanghai). 2022; 54: 1599-609.

Crossref Google Scholar
12

Hong X, Qiao S, Li F, Wang W, Jiang R, Wu H, et al. Whole-genome sequencing reveals distinct genetic bases for insulinomas and non- functional pancreatic neuroendocrine tumours: leading to a new classification system. Gut. 2020; 69: 877-87.

Crossref Google Scholar
13

Mo S, Zong L, Chen X, Chang X, Lu Z, Yu S, et al. High mast cell density predicts a favorable prognosis in patients with pancreatic neuroendocrine neoplasms. Neuroendocrinology. 2022; 112: 845-55.

Crossref Google Scholar
14

Jacenik D, Lebish EJ, Beswick EJ. MK2 promotes the development and progression of pancreatic neuroendocrine tumors mediated by macrophages and metabolomic factors. Int J Mol Sci. 2022; 23: 13561.

Crossref Google Scholar
15

Zhang WH, Wang WQ, Han X, Gao HL, Xu SS, Li S, et al. Infiltrating pattern and prognostic value of tertiary lymphoid structures in resected non-functional pancreatic neuroendocrine tumors. J Immunother Cancer. 2020; 8: e001188.

Crossref Google Scholar
16

Wei M, Xu J, Hua J, Meng Q, Liang C, Liu J, et al. From the immune profile to the immunoscore: Signatures for improving postsurgical prognostic prediction of pancreatic neuroendocrine tumors. Front Immunol. 2021; 12: 654660.

Crossref Google Scholar
17

Beauchamp RD, Coffey RJ, Jr., Lyons RM, Perkett EA, Townsend CM, Jr., Moses HL. Human carcinoid cell production of paracrine growth factors that can stimulate fibroblast and endothelial cell growth. Cancer Res. 1991; 51: 5253-60.

Google Scholar
18

Wimmel A, Wiedenmann B, Rosewicz S. Autocrine growth inhibition by transforming growth factor β-1 (TGFβ-1) in human neuroendocrine tumour cells. Gut. 2003; 52: 1308-16.

Crossref Google Scholar
19

Cuny T, de Herder W, Barlier A, Hofland LJ. Role of the tumor microenvironment in digestive neuroendocrine tumors. Endocr Relat Cancer. 2018; 25: R519-44.

Crossref Google Scholar
20

Lou X, Qin Y, Xu X, Yu X, Ji S. Spatiotemporal heterogeneity and clinical challenge of pancreatic neuroendocrine tumors. Biochim Biophys Acta Rev Cancer. 2022; 1877: 188782.

Crossref Google Scholar
Cancer Biology & Medicine
Volume 20 Issue 10,
October 2023
Pages 721-727
DOI: 10.20892/j.issn.2095-3941.2023.0284
Cite this article:
Xu J, Zhang W, Lou X, et al. Recent research hotspots in sequencing and the pancreatic neuroendocrine tumor microenvironment. Cancer Biology & Medicine, 2023, 20(10): 721-727. https://doi.org/10.20892/j.issn.2095-3941.2023.0284
Metrics & Citations  
Article History
Copyright
Rights and Permissions
Return