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Expert Opinion | Open Access

Standards for the culture and quality control of umbilical cord mesenchymal stromal cells for neurorestorative clinical application (2017)

Qiang Ao1,*, Juan Xiao2,3,*, Yanqiu Yu4, Gengsheng Mao2, Qingyan Zou5, Wenyong Gao2,3, Hongyun Huang2,3( )
Department of Tissue Engineering, China Medical University, Shen Yang
Institute of Neurorestoratology, General Hospital of Armed Police Forces, Beijing
Cell Therapy Center, Beijing Hongtianji Neuroscience Academy, Beijing
Department of Pathophysiology, China Medical University, Shen Yang
Guangdong 999 Brain Hospital, Guangzhou, People’s Republic of China

*These authors contributed equally to this work

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Abstract

Formulating common standards for the culture and quality control of umbilical cord mesenchymal stromal cells (MSCs) is crucial for the standardization of clinical neurorestorative therapy. But to date, there have been no standardized guidelines for the culture and quality control of MSCs in neurorestorative clinical application. Based on a relatively comprehensive review of published clinical studies as well as the existing methods of MSC culture and quality control, the Chinese Association of Neurorestoratology has developed standards for the culture and quality control of umbilical cord MSCs which possess the potential in neurorestorative clinical application. These guidelines include standardized training and management procedures for laboratory operators; standardized use and management of materials and equipment; standardized collection, culture and proliferation of umbilical cord MSCs; standardized management for cell preservation, transport and related safeguard measures; as well as standardization of a clean environment, routine maintenance and related tests and examinations and so on. These guidelines represent the minimum required standards for the culture and quality control of umbilical cord MSCs for potential use in current neurorestorative clinical therapy, and will be further optimized according to the progress of preclinical and clinical studies.

Keywords

standardizationcell culturequality controlmesenchymal stromal cellsclinical treatmentneurorestoratologytranslational medicine

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Journal of Neurorestoratology
Volume 6 Issue 1,
December 2018
Pages 11-15
DOI: 10.2147/JN.S148686
Cite this article:
Ao Q, Xiao J, Yu Y, et al. Standards for the culture and quality control of umbilical cord mesenchymal stromal cells for neurorestorative clinical application (2017). Journal of Neurorestoratology, 2018, 6(1): 11-15. https://doi.org/10.2147/JN.S148686

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Published: 26 June 2018
© The authors 2018.

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