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Review | Open Access

Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review

Munyaradzi Kamudzandu, Paul Roach, Rosemary A Fricker, Ying Yang( )
Institute for Science and Technology in Medicine, School of Medicine, Keele University, Stoke-on-Trent, UK
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Abstract

Restoration of function following damage to the central nervous system (CNS) is severely restricted by several factors. These include the hindrance of axonal regeneration imposed by glial scars resulting from inflammatory response to damage, and limited axonal outgrowth toward target tissue. Strategies for promoting CNS functional regeneration include the use of nanotechnology. Due to their structural similarity, synthetic nanofibers could play an important role in regeneration of CNS neural tissue toward restoration of function following injury. Two-dimensional nanofibrous scaffolds have been used to provide contact guidance for developing brain and spinal cord neurites, particularly from neurons cultured in vitro. Three-dimensional nanofibrous scaffolds have been used, both in vitro and in vivo, for creating cell adhesion permissive milieu, in addition to contact guidance or structural bridges for axons, to control reconnection in brain and spinal cord injury models. It is postulated that nanofibrous scaffolds made from biodegradable and biocompatible materials can become powerful structural bridges for both guiding the outgrowth of neurites and rebuilding glial circuitry over the "lesion gaps" resulting from injury in the CNS.

Keywords

regenerationalignmentscaffoldnanofibrous scaffoldCNS

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Journal of Neurorestoratology
Volume 3 Issue 1,
December 2015
Pages 123-131
DOI: 10.2147/JN.S70337
Cite this article:
Kamudzandu M, Roach P, Fricker RA, et al. Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review. Journal of Neurorestoratology, 2015, 3(1): 123-131. https://doi.org/10.2147/JN.S70337

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Published: 02 December 2015
© 2015 The Author(s).

© 2015 Kamudzandu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
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