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Article | Open Access

Aging-related alternative splicing landscapes across human T cells

Lipeng Mao1,2,§, Yue Zhu1,2,§, Bei Zhang1,2,§, Guangjie Wu3,§, Qiuyue Feng1,2, Oscar Junhong Luo1,2( )
Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou 510630, China
Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, School of Medicine, Jinan University, Guangzhou 510630, China
Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou 510630, China

§ These authors contributed equally to this work.

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Abstract

As age-related diseases escalate, deciphering molecular mechanism of immune aging is vital. T cells, crucial in adaptive immunity, undergo aging-related transformations in quantity and quality. The interconnection between aging and alternative splicing of gene expression in different T cell subtype is still unclear. Thus, we examined age-related gene alternative splicing in numerous immune cell subgroups, constructing an aging-associated atlas for alternative splicing across human T cell subtypes. Our study identified numerous age-related alternative splicing events in genes linked to T cell activation, differentiation, migration, and apoptosis. Genes like PDCD4 and ARCN1 with age group-specific alternative splicing events and implicated in T cell aging hint at potential therapeutic targets for immune aging. Overall, our findings present a comprehensive alternative splicing atlas for healthy aging-related molecular programs, introducing fresh perspectives for T cell transformation regulation during aging, and inspiring new approaches for novel T cell aging intervention molecules and methods.

Keywords

agingimmune agingalternative splicingT cells

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Aging Research
Volume 1 Issue 1,
September 2023
Article number: 9340007
DOI: 10.26599/AGR.2023.9340007
Cite this article:
Mao L, Zhu Y, Zhang B, et al. Aging-related alternative splicing landscapes across human T cells. Aging Research, 2023, 1(1): 9340007. https://doi.org/10.26599/AGR.2023.9340007

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Received: 27 March 2023
Revised: 26 April 2023
Accepted: 27 April 2023
Published: 29 May 2023
© The Author(s) 2023. Aging Research published by Tsinghua University Press.

The articles published in this open access journal are distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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