Willingness and influencing factors to be vaccinated against herpes zoster and pneumococcus of people aged 50 years and over in Xicheng District parks, Beijing

Junqing Song; Zhaonan Zhang; Xia Chen; Chao Wang; Chong Teng; Lirong Wang; Yifan Song; Jichuan Shen; lunguang Liu; Yingxin Pei

doi:10.26599/AGR.2024.9340027

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Article | Open Access

Willingness and influencing factors to be vaccinated against herpes zoster and pneumococcus of people aged 50 years and over in Xicheng District parks, Beijing

Junqing Song^{¹^,²^,^§}, Zhaonan Zhang^{¹^,³^,⁴^,^§}, Xia Chen^{¹^,⁵}, Chao Wang^{¹^,⁶}, Chong Teng^{¹^,⁷}, Lirong Wang^{¹^,⁸}, Yifan Song^{³^,⁴}, Jichuan Shen^{¹^,⁹}, lunguang Liu^{¹^,¹⁰}, Yingxin Pei^¹()

1Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China

2Office of Chronic Disease and Ageing Health Management, Chinese Center for Disease Control and Prevention, Beijing 102206, China

3National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing 102206, China

4National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 102206, China

5Luzhou Center for Disease Control and Prevention, Luzhou 646000, China

6School of Public Health, Peking University, Beijing 100191, China

7Dongcheng District Center for Disease Control and Prevention, Beijing 100009, China

8Heilongjiang Center for Disease Control and Prevention, Harbin 150030, China

9Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China

10Sichuan Center for Disease Control and Prevention, Chengdu 610041, China

^§ These authors contributed equally to this work.

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Abstract

Objective

To assess the willingness to receive herpes zoster vaccines (HZV) and 23-valent pneumococcal polysaccharide vaccines (PPSV23) among population aged ≥ 50 years in Xicheng District, Beijing, China.

Results

36.59% and 40.98% of respondents ≥ 50 years of age were willing to receive HZV and PPSV23 with out-of-pocket expenses, and 54.63% of those were willing to receive PPSV23 for free of charge. Willingness to vaccinate against herpes zoster was associated with female sex and higher confidence in vaccine effectiveness, and willingness to vaccinate against PPSV23 was associated with younger age, higher confidence in vaccine effectiveness and having heard of PPSV23.

Conclusion

The lower vaccination rate and willingness to vaccinate HZV and PPSV23 were found among individuals aged ≥ 50 years in Xicheng District, Beijing, China. We suggest the vaccination awareness among elderly should be improved.

Methods

We conducted a cross-sectional survey of people ≥ 50 years of age in three parks of Xicheng District. Logistic regression analyses were performed to determine factors associated with willingness to be vaccinated.

Keywords

elderly herpes zoster vaccine pneumococcal vaccine willingness

References

[1]

Harbecke, R., Cohen, J. I., Oxman, M. N. Herpes zoster vaccines. The Journal of Infectious Diseases, 2021 , 224(12 suppl 2): S429–S442. https://doi.org/10.1093/infdis/jiab387

Crossref

[2]

Prayitno, A., Supriyatno, B., Munasir, Z., Karuniawati, A., Hadinegoro, S. R. S., Prihartono, J., Safari, D., Sundoro, J., Khoeri, M. M. Pneumococcal nasopharyngeal carriage in Indonesia infants and toddlers post-PCV13 vaccination in a 2+1 schedule: A prospective cohort study. PLoS One, 2021, 16(1): e0245789. https://doi.org/10.1371/journal.pone.0245789.

Crossref Google Scholar

[3]

World Health Organization. Considerations for pneumococcal vaccination in older adults [EB/OL]. https://www.who.int/publications/i/item/WER9623-217-228. (accessed on 2024-04-14

[4]

Fang, E. F., Xie, C., Schenkel, J. A., Wu, C., Long, Q., Cui, H., Aman, Y., Frank, J., Liao, J., Zou, H. et al. A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks. Ageing Research Reviews, 2020, 64: 101174. https://doi.org/10.1016/j.arr.2020.101174.

Crossref Google Scholar

[5]

Mbinta, J. F., Wang, A. X., Nguyen, B. P., Paynter, J., Awuni, P. M. A., Pine, R., Sporle, A. A., Simpson, C. R. Herpes zoster vaccine effectiveness against herpes zoster and postherpetic neuralgia in New Zealand: A retrospective cohort study. The Lancet Regional Health - Western Pacific, 2023, 31: 100601. https://doi.org/10.1016/j.lanwpc.2022.100601.

Crossref Google Scholar

[6]

Cripps, A. W., Folaranmi, T., Johnson, K. D., Musey, L., Niederman, M. S., Buchwald, U. K. Immunogenicity following revaccination or sequential vaccination with 23-valent pneumococcal polysaccharide vaccine (PPSV23) in older adults and those at increased risk of pneumococcal disease: A review of the literature. Expert Review of Vaccines, 2021, 20(3): 257–267. https://doi.org/10.1080/14760584.2021.1889374.

Crossref Google Scholar

[7]

World Health Organization. Varicella and herpes zoster vaccines: WHO position paper, June 2014 [EB/OL]. https://www.who.int/publications/i/item/who-wer-8925-265-288. (accessed on 2024-04-14

[8]

Commission B M H. Implementation plan for pneumococcal vaccination of people aged 65 and over in Beijing [EB/OL]. https://wjw.beijing.gov.cn/zwgk_20040/ghjh1/201912/t20191216_1242732.html. (accessed on 2024-04-14

[9]

Jiang, B., Wang, Q., Wang, Z., Xu, Y., Yang, T., Yang, W., Jia, M., Feng, L. Willingness to accept herpes zoster vaccines and the influencing factors in China. BMC Infectious Disease, 2022, 22(1): 888. https://doi.org/10.1186/s12879-022-07840-2.

Crossref Google Scholar

[10]

Jiang, M., Yao, X., Li, P., Fang, Y., Feng, L., Hayat, K., Shi, X., Gong, Y., Peng, J., Atif, N. Impact of video-led educational intervention on uptake of influenza vaccine among the elderly in Western China: A community-based randomized controlled trial. BMC Public Health, 2022, 22(1): 1128. https://doi.org/10.1186/s12889-022-13536-8.

Crossref Google Scholar

[11]

Abu-Rish, E. Y., Barakat, N. A. The impact of pharmacist-led educational intervention on pneumococcal vaccine awareness and acceptance among elderly in Jordan. Human Vaccines & Immunotherapeutics, 2021, 17(4): 1181–1189. https://doi.org/10.1080/21645515.2020.1802973.

Crossref Google Scholar

[12]

Kirubarajan, A., Lynch, M., Nasreen, S., Gebretekle, G. B., Fadel, S. A., Crowcroft, N. S., Allin, S. Increasing pneumococcal vaccine uptake in older adults: A scoping review of interventions in high-income countries. BMC Geriatrics, 2023, 23(1): 2. https://doi.org/10.1186/s12877-022-03653-9.

Crossref Google Scholar

[13]

Liu, S., Xu, E., Liu, Y., Xu, Y., Wang, J., Du, J., Zhang, X., Che, X., Gu, W. Factors associated with pneumococcal vaccination among an urban elderly population in China. Human Vaccines & Immunotherapeutics, 2014, 10(10): 2994–2999. https://doi.org/10.4161/21645515.2014.972155.

Crossref Google Scholar

[14]

Wang, M., Long, C., Hu, M. Z., Wang, Y. S., Xia, Y. Q., Yuan, B. B., Zhu, D. W., He, P. A study on knowledge, attitude, and vaccination behavior of herpes zoster vaccine among urban residents in selected areas of China. Chinese Journal of Epidemiology, 2023, 44(6): 899–904. (in Chinese)

Google Scholar

[15]

Guo, J., Zhang, H. J., Lv, Y., Lai, X. Z., Feng, H. Y. F., Wang, J. H., Zhang, H. N., Fang, H. Health and economic evaluation of immunization strategies using 23-valent pneumococcal polysaccharide vaccine: a systematic review. Chinese Journal of Vaccines and Immunization, 2021, 27(6): 705–710.

Google Scholar

[16]

Shao, W., Chen, X., Zheng, C., Wang, G., Zhang, B., Zhang, W. Pneumococcal vaccination coverage and willingness in mainland China. Tropical Medicine & International Health, 2022, 27(10): 864–872. https://doi.org/10.1111/tmi.13809.

Crossref Google Scholar

[17]

Peng, X. D., Xu, Y. Y., Hu, X. J., Guo, L. J., Bo Jia. Analysis of the status and effects of the public-funded free 23-valent pneumococcal polysaccharide vaccination among elderly aged 60 years or older in Shanghai, 2013–2023. Journal of Tuberculosis and Lung Disease, 2023, 4(4): 283–294.

Google Scholar

[18]

Kobayashi, M., Pilishvili, T., Farrar, J. L., Leidner, A. J., Gierke, R., Prasad, N., Moro, P., Campos-Outcalt, D., Morgan, R. L., Long, S. S. et al. Pneumococcal vaccine for adults aged ≥19 years: Recommendations of the advisory committee on immunization practices, United States, 2023. MMWR Recomm Rep, 2023, 72(3): 1545–8601. https://doi.org/10.15585/mmwr.rr7203a1.

Crossref Google Scholar

[19]

Dooling, K. L., Guo, A., Patel, M., Lee, G. M., Moore, K., Belongia, E. A., Harpaz, R. Recommendations of the advisory committee on immunization practices for use of herpes zoster vaccines. MMWR Morb Mortal Wkly Rep, 2018, 67(3): 103–108. https://doi.org/10.15585/mmwr.mm6703a5.

Crossref Google Scholar

[20]

Hung, M.-C., Srivastav, A., Lu, P.-J., Black, C. L., Jatlaoui, T. C., Lindley, M. C., Singleton, J. A. Vaccination coverage among adults in the United States, National Health interview survey, 2021. https://www.cdc.gov/vaccines/imz-managers/coverage/adultvaxview/pubs-resources/vaccination-coverage-adults-2021.html#print. (accessed on 2024-04-14

[21]

Bai, Y.H., Ma, W., Lv, M., Wu, J., Chen, Q. P. Willingness to receive pneumococcal vaccination and factors influencing willingness among people over 65 years old in Chaoyang district of Beijing city. Chinese Journal of Vaccines and Immunization, 2018, 24(4): 462–466. (in Chinese)

Google Scholar

Aging Research

Volume 2 Issue 2,
June 2024

Article number: 9340027

DOI: 10.26599/AGR.2024.9340027

Cite this article:

Song J, Zhang Z, Chen X, et al. Willingness and influencing factors to be vaccinated against herpes zoster and pneumococcus of people aged 50 years and over in Xicheng District parks, Beijing. Aging Research, 2024, 2(2): 9340027. https://doi.org/10.26599/AGR.2024.9340027

Return

Table 1Characteristics of participants aged 50 years and over

Variables	Number	Percentage
Gender
Male	75	36.59%
Female	130	63.41%
Age (years)
50–64	79	38.54%
65–79	111	54.14%
≥80	15	7.32%
Education background
Junior high school or below	69	33.7%
High school	70	34.1%
University or above	66	32.2%
Family income (CNY/month/person)
< 3000	26	12.68%
≥ 3000	75	36.59%
≥ 5000	67	32.68%
≥ 7000	37	18.05%
Physical condition
Poor	116	56.6%
Fair	75	36.6%
Good	14	6.8%
Have you heard of HZV?
Never	93	45.37%
Yes	112	54.63%
Can HZV effectively prevent disease?
Yes	83	40.49%
No	122	59.51%
Is herpes zoster a severe illness?
Yes	125	60.98%
No	80	39.02%
Have you heard of PPSV23?
Never	87	42.44%
I\'ve heard of PPV23	118	57.56%
Can PPSV23 effectively prevent disease?
Yes	70	34.15%
No	135	65.85%

Table 2Multifactorial logistic regression analysis of willingness to receive HZV in people over the age of 50 years

Variables	Total (N)	Willingness		OR (95%CI)
Variables	Total (N)	N	Percentage	OR (95%CI)
Gender
Male	75	19	25.33%	Reference group
Female	130	56	43.08%	2.44 [1.16, 5.16]
Age (years)
50–64	84	40	47.62%	Reference group
65–79	106	33	31.13%	0.49 [0.24, 1.02]
≥ 80	15	2	13.33%	0.25 [0.05, 1.36]
Education background
Junior high school or below	69	21	30.43%	Reference group
High school	70	19	27.14%	0.69 [0.29, 1.63]
University or above	66	35	53.03%	1.42 [0.53, 3.82]
Family income (CNY/month/person)
< 3000	26	10	38.46%	Reference group
≥ 3000	75	25	33.33%	0.58 [0.2, 1.69]
≥ 5000	67	18	26.87%	0.41 [0.13, 1.28]
≥ 7000	37	22	59.46%	1.03 [0.26, 4.01]
Physical condition
Poor	116	43	37.07%	Reference group
Fair	75	30	40%	1.41 [0.68, 2.96]
Good	14	2	14.29%	0.27 [0.05, 1.51]
Have you heard of HZV?
Never	93	47	50.54%	Reference group
I\'ve heard of HZV	112	28	25%	0.57 [0.26, 1.24]
Can HZV effectively prevent disease?
Yes	83	45	54.22%	Reference group
No	122	30	24.59%	0.46 [0.22, 0.98]
Is herpes zoster a severe illness?
Yes	125	54	43.2%	Reference group
No	80	21	26.25%	0.54 [0.26, 1.1]

Table 3Multifactorial Logistic regression analysis of willingness to receive free PPV23 in people over 50 years of age

Variables	Total (N)	Willingness		OR (95%CI)
Variables	Total (N)	N	Percentage	OR (95%CI)
Gender
Male	75	33	44%	Reference group
Female	130	79	60.77%	1.68 [0.81, 3.46]
Age (years)
50–64	84	57	67.86%	Reference group
65–79	106	50	47.17%	0.3 [0.14, 0.67]
≥ 80	15	5	33.33%	0.22 [0.05, 0.89]
Education background
Junior high school or below	69	33	47.83%	Reference group
High school	70	34	48.57%	0.61 [0.27, 1.39]
University or above	66	45	68.18%	0.66 [0.24, 1.84]
Family income (CNY/month/person)
< 3000	26	16	61.54%	Reference group
≥ 3000	75	38	50.67%	0.43 [0.14, 1.27]
≥ 5000	67	28	41.79%	0.45 [0.15, 1.36]
≥ 7000	37	30	81.08%	1.64 [0.37, 7.28]
Physical condition
Poor	116	63	54.31	Reference group
Fair	75	43	57.33	1.47 [0.68, 3.19]
Good	14	6	42.86	0.62 [0.17, 2.24]
Have you heard of PPV23?
Never	87	66	75.86	Reference group
I\'ve heard of PPV23	118	46	38.98	0.22 [0.1, 0.47]
Can PPSV23 effectively prevent disease?
Yes	70	56	80	Reference group
No	135	56	41.48	0.22 [0.1, 0.48]

Table 4Reasons for unwillingness to vaccinate HZV and PPSV23

Reasons for unwillingness to vaccinate HZV	N	Percentage	Reasons for unwillingness to vaccinate PPSV23	N	Percentage
Healthy people are not required to be vaccinated.	44	33.85%	Lack of awareness regarding the pneumococcal vaccine.	32	34.41%
Concerning about AEFI	39	30%	Concerning about AEFI	26	27.96%
I never heard of HZV	27	20.77%	Healthy people are not required to be vaccinated.	21	22.58%
Already had herpes zoster.	21	16.15%	PPSV23 cannot prevent pneumococcal diseases.	14	15.05%
HZV cannot prevent herpes zoster.	20	15.38%	No risk of infection	12	12.9%
HZV is expensive	17	13.08%	I never heard of PPSV23 free vaccination policy	6	6.45%
Have vaccination contraindications	12	9.23%
Herpes zoster is not a severe illness.	7	5.38%