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Review Article | Open Access

Genetically encoded neural activity indicators

Fang Luo1, Yin Wei1, Ziyue Wang1, Minmin Luo2, Ji Hu1( )
School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
National Institute of Biological Sciences, Beijing 102206, China
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Abstract

Recent years have witnessed the fascinating development of imaging approaches to studying neural activities; this progress has been based on an influx of ideas and methods from molecular biology and optical engineering. Here we review the design and application of genetically encoded indicators for calcium ions, membrane potential and neurotransmitters. We also summarize common strategies for the design and optimization of genetically encoded neural activity indicators.

Keywords

calcium imagingneural activitymembrane potential probeneurotransmitter reporter

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Brain Science Advances
Volume 4 Issue 1,
September 2018
Pages 1-15
DOI: 10.26599/BSA.2018.9050007
Cite this article:
Luo F, Wei Y, Wang Z, et al. Genetically encoded neural activity indicators. Brain Science Advances, 2018, 4(1): 1-15. https://doi.org/10.26599/BSA.2018.9050007

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Received: 02 September 2018
Revised: 27 September 2018
Accepted: 15 October 2018
Published: 25 November 2018
© The authors 2018

This article is published with open access at journals.sagepub.com/home/BSA

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